Renal dysfunction and serious infections after open-heart surgery

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Renal dysfunction and serious infections after open-heart surgery Charuhas V. Thakar, Jean-Pierre Yared, Sarah Worley, Kathy Cotman, Emil P. Paganini  Kidney International  Volume 64, Issue 1, Pages 239-246 (July 2003) DOI: 10.1046/j.1523-1755.2003.00040.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 The relationship between preoperative creatinine clearance (mL/min) and frequency of infection. The frequency of sepsis syndrome and septic shock is indicated by the shaded portion. N = 22,587; two patients were missing information for age at surgery. Kidney International 2003 64, 239-246DOI: (10.1046/j.1523-1755.2003.00040.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Shown is the frequency of infections by both of our definitions, including patients with postoperative acute renal failure (ARF). The shaded portion represents those patients who met the criteria for sepsis syndrome and septic shock. Kidney International 2003 64, 239-246DOI: (10.1046/j.1523-1755.2003.00040.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3A The frequency of infections in patients who developed acute renal failure (ARF) requiring dialysis, categorized based on preoperative creatinine clearance is illustrated.N = 411; one patient in this subgroup was missing information for age at surgery. Kidney International 2003 64, 239-246DOI: (10.1046/j.1523-1755.2003.00040.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3B The frequency of infections in patients who developed acute renal failure (ARF) not requiring dialysis, categorized based on preoperative creatinine clearance is shown. Kidney International 2003 64, 239-246DOI: (10.1046/j.1523-1755.2003.00040.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 The relationship between preoperative creatinine clearance (mL/min) and frequency of infections after excluding those patients who developed postoperative acute renal failure (ARF) by either of our definitions.N = 21,470; 2 patients were missing information for age at surgery, one of which developed ARF requiring dialysis. Kidney International 2003 64, 239-246DOI: (10.1046/j.1523-1755.2003.00040.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 The frequency of infections within each category of type of open-heart surgery compared according to preoperative creatinine clearance. The cutoff point at creatinine clearance of 60mL/min was based upon estimates on the logit scale, as well as the categories of preoperative renal dysfunction. *P < 0.001; **P < 0.003. Kidney International 2003 64, 239-246DOI: (10.1046/j.1523-1755.2003.00040.x) Copyright © 2003 International Society of Nephrology Terms and Conditions