HISTOLOGY OF PANCREAS.

Slides:



Advertisements
Similar presentations
Digestive glands Department of Histology and Embryology Zhang ximei.
Advertisements

In the name of God Digestive gland Dr. Zahiri.
Pancreas & diabetes Željka Kušter Mentor: A. Žmegač Horvat.
PANCREAS ANATOMY esophagus stomach ductus choledocus pancreas duodenum
Structure of the liver, gallbladder and pancreas
PANCREAS Objectives The student should be able to describe: 1.The endocrine part of the pancreas within the exocrine part. 2.The histological features.
500X 1000X Name the organ from which these slides were prepared.
The Pancreas and Diabetes Mellitus
Histology of Tongue, Liver & Pancreas
PANCREAS AND DIABETES Valerija Vrhovnik Mentor: A. Žmegač Horvat.
Pancreas, Liver, and gallbladder Metallic 0 Mind.
Digestive glands. General outline  small digestive glands distributed in the wall of digestive tract esophageal glands, gastric glands and intestine.
ACCESSORY DIGESTIVE GLANDS
بسم الله الرحمن الرحيم.
DIGESTIVE SYSTEM III. VII. Digestive organs - background information. A. There are a number of organs associated with the digestive tract that assist.
DIGESTIVE SYSTEM LIVER PANCREAS.
Liver and Pancreas Department of Histology and Embryology Medical college in Three Gorges University.
DIGESTIVE SYSTEM 2 Intestine
Chapter 13 Disorders of the Pancreas
Robert Scranton ©2008.  Develops from _______ & ________ buds of the duodenum  The portion becomes the _____________ and a portion of the ______. 
DIGESTIVE GLANDS - CHA - THE LIVER - THE GREATEST MEASUREMENT OF ORGAN IN HUMAN ( 1,5 KG ), CONSIST OF 4 LOBUS. - CAPSUL CONSIST OF CONNECTIVE TISSUE,
DIGESTIVE GLANDS Department of Histology and Embryology
IN THE NAME OF GOD THE COMPASSIONATE THE MERCIFUL
Digestive System Digestive Glands. Components of Digestive Glands Small digestive glands: found in the wall of digestive tract Accessory glands (large.
PANCREAS Objectives The students should be able to describe: 1. The endocrine part of the pancreas within the exocrine portion. 2. The histological features.
The extrinsic glands of the digestive system include the major salivary glands, the pancreas, and the liver, all of which are located outside the wall.
Digestion (continued) Biliary system. Biliary System  Liver Unique to subphylum Conservative form and function. Largest gland in body Divided into lobes.
Unit 2 – Digestion Module Histology of the pancreas and biliary tract Safaa El Bialy (MD,PhD) Ottawa University.
Histology Pre-Lab. # 11 6/4/2016 LIVER/ GALL BLADDER & PANCREAS BY PROF. DR.ANSARI MBBS SEMESTER I 1.
Classification of Glands Glands Associated with the Gastrointestinal Tract.
Unit 2 – Endocrine Module Histology of the endocrine pancreas
Dr. ANAND SRINIVASAN.  Good regenerative capacity  Hence used for transplantation.
بسم الله الرحمن الرحيم.
HISTOLOGY OF SALIVARY GLANDS Dr. Sobia Ibrahim Assistant Professor Anatomy, KEMU.
Digestive gland Dr. Maria Zahiri.
SALIVARY GLANDS AND PANCREAS
BILIARY PASSAGES & PANCREAS Objectives: The student should be able to identify & describe the histological features of: 1.Intrahepatic biliary passages.
DIGESTIVE SYSTEM Associated Glands: Associated Glands: 1.Salivary glands. 2.Liver. 3.Pancreas.
Digestive System Digestive Glands. ◇ small digestive glands: found in the wall of digestive tract. ◇ accessory glands (large digestive glands) : salivary.
The pancreas is mixed exocrine- endocrine gland that produces digestive enzymes and hormones. The enzymes are stored and released by cells.
Digestive System Glands Zukesti Effendi Zulham Department of Histology Faculty of Medicine USU histologi.usu.ac.id.
Gastro-Intestinal Tract - 2 Objectives: At the end of this session you should be able to: 1. Recognise and describe a section of liver appreciating how.
Histology of The Accessory Organs of The Digestive System.
Ultrastructure of a hepatocyte. RER, rough endoplasmic reticulum; SER, smooth endoplasmic reticulum. x10,000.
Lecture DIGESTIVE SYSTEM part 2
د. عماد غانم د.عماد غانم د.دد..
BILIARY PASSAGES & PANCREAS
BILIARY PASSAGES & PANCREAS
BILIARY PASSAGES & PANCREAS
Types of Glands (1). Number of cells the glands are made up of:
Accessory organ human liver
PARATHYROID GLANDS Objectives: Students should be able to:
Organization of the pancreas. A
Anatomy of the Pancreas
PANCREAS Pathology Dept, KSU GIT Block.
Lecture Eight DIGESTIVE GLANDS Salivary glands Pancreas Liver
بسم الله الرحمن الرحيم LIVER Gall bladder Pancreas Dr. Rana Mustafa
Digestive glands.
A Presentation by Sam, Marcelo and Gassan
The Pancreas.
Pancreas (No.29) Liver (No.30)
3.Submandibular gland 下颌下腺(No.32)
Digestive System Digestive Glands.
Communication and Homeostasis
Chapter 14 Digestive gland
SALIVARY GLANDS Objectives
BILIARY PASSAGES & PANCREAS
Accessory Organs of the Digestive System Dr. Buthaina Ibrahem Al-ezzi
Presentation transcript:

HISTOLOGY OF PANCREAS

PANCREAS Has exocrine & endocrine functions Parts Capsule Septa – lobules Secretions: Enzymes Hormones

EXOCRINE PANCREAS COMPOUND ACCINAR GLAND Pear shaped accini 5-8 pyramidal cells Reticular fibers support accini Inter- lobular CT contains: Blood vessels Nerves Lymphatic

EXOCRINE PANCREAS ACCINI Cells have spherical basal nucleus Basal cytoplasm basophilic – RER mitochondria Golgi apparatus Apical zymogen granules – maximum in fasted person Centroacinar cells

EXOCRINE PANCREAS DUCTS Intercalated ducts NO striated ducts Large intralobular ducts – high cuboidal epithelium Interlobular ducts – columnar epithelium Larger ducts Main duct

SECRETIONS OF EXOCRINE PANCREAS Proteases (trypsinogen & chymotrypsinogen etc.) Amylase Lipase Nucleases (DNAase & RNAase)

MEDICAL APPLICATION ACUTE NECROTIZING PANCREATITIS Proenzyme activated Digest pancreatic tissue Causes: Alcoholism Gall stones Trauma Drugs

MEDICAL APPLICATION Extreme malnutrition e.g. kwashiorkor Atrophy of pancreatic acinar cells Loss of RER Digestive enzyme production hindered

ENDOCRINE PANCREAS (ISLETS) Embedded within accini 100-200µm diameter > 1 million islets Abundant in tail

ISLETS OF LANGERHANS Reticular fibers surround each islet Small polygonal cells Cells lightly stained Arranged in anastomosing cords Fenestrated capillaries between cords Autonomic fibers

ISLETS OF LANGERHANS CELLS OF ISLETS A /α cells- glucagon, at periphery B /β cells- insulin, at center- numerous D /δ cells- somatostatin, scattered F /PP cells- pancreatic polypeptide Enterochromaffin cells- motilin,secretin, substane -P

BLOOD SUPPLY Rich arterial supply Major BV run in interlobular CT Intralobular BV Arterioles pass to islets Extensive capillary network First supply peripheral cells Blood from islets pass to supply exocrine tissue Hormones effect acinar function

COMPARISON PAROTID GLAND PANCREAS

MEDICAL APPLICATION INSULIN DEPENDENT / TYPE I DIABETES (juvenile) Autoimmune disease Partial or total destruction of β cells Lack of insulin INSULIN INDEPENDENT DIABETES / TYPE II Adult onset Associated with obesity Failure of cell to respond to insulin TUMOURS OF ISLETS May secrete anyone of the hormones May secrete more than one hormone