A BDCA BDCA BDCA CD CD1a CD11b CD11c 100 101 102 103 104 GM-CSF

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Presentation transcript:

A BDCA-1 BDCA-2 BDCA-4 CD123 CD1a CD11b CD11c 100 101 102 103 104 GM-CSF IL-4 DC pDC B ns * C IL-4 DC 0,00002 0,00004 0,00006 0,00008 0,0001 0,00012 0,001 * 0,0008 30 * CD2AP/b-actin TLR7/b-actin 0,0006 0,0004 25 0,0002 20 IFN a/b (U/ml) ns ns 15 GM-CSF IL-4 DC 0,0016 0,0006 10 0,0014 0,0012 0,0005 IRF8/b-actin 0,001 0,0004 5 0,0008 TLR9/b-actin 0,0003 0,0006 0,0002 0,0004 0,0002 0,0001 Untreated NDV Figure S3. Phenotypic, molecular and functional features of IL-4 DC. A. Flow cytometry analysis of lineage-DC markers in IL-4 DC and GM-CSF-treated monocytes. Broken line histograms represent isotype controls. Representative data of 1 experiment out of 3 are shown. B. Expression of pDC–related molecular markers evaluated by qRT-PCR in the same DC populations indicated in panel A. The data are presented as the means ± SD of 3 independent experiments. C. Production of IFN-I in IL-4 DC and pDC after in vitro infection with NDV. DC populations were infected with NDV for 1 hour. Virus was then washed out and the supernatant was harvested after 18 hour incubation and assayed for IFN-I bioactivity, as described in Materials and Methods. Data are representative of 2 independent experiments. Statistical analyses were performed by using Mann-Whitney test (*p≤0.0001, ns=not significant). .