Reaction mechanism of the Michael addition reaction between a nucleophile and a polarized double bond. Source: Nucleophilic Substitution, Addition, and.

Slides:



Advertisements
Similar presentations
Structures and pKa values for acetic acid and benzoic acid
Advertisements

Adhesive capsulitis of the shoulder
Structures of irreversible kinase inhibitors afatinib and ibrutinib
Wong-Baker FACES pain scale (Wong-Baker FACES Foundation (2015)
Pathophysiology of esophageal reflux disease
The H double advancement flap: (a) excision of tumour with planned flaps; (b) pulling the flaps together; (c) flaps sutured to repair defect Source: Skin.
The cycle of injury and reinjury resulting from rotator cuff impingement. Source: Chapter 3. Sports Medicine, Current Diagnosis & Treatment in Orthopedics,
Formation of vitamin C radical by reduction of the vitamin E radical
Nine patterns of inflammatory skin disease. (See also Table 8–1.)
Forearm support for sustained work at the computer.
Diagnostic algorithm for normocytic anemia.
Staging of endometriosis
Colles fracture: (a) dinner-fork deformity; (b) lateral X-ray view; (c) anteroposterior X-ray view; (d) radial (lateral) tilt of distal segment Source:
Umbilical artery catheter insertion. (A) Artery dilation
Mechanism of proteolysis by the serine protease chymotrypsin
(Data from Rosenfeld RL. N Engl J Med 2005; 353:2578–2588.)
Small bowel Crohn disease.
SPECT images from a brain scan obtained in the interictal state in a child with seizures demonstrates marked asymmetric uptake in the left temporal lobe.
Local anesthetic infiltration into the chest wall for tube thoracostomy. (Reproduced, with permission, from Reichman EF, Simon RR: Emergency Medicine Procedures.
“Mount Fuji Sign.” While not classic for the typical peaked pneumocephalus, note the compressive nature of the air collection at the surgical site. Source:
IMAGE COURTESY OF CYCLEFIT UK
Bioavailability of a drug from an immediate-release tablet containing 50 mg of drug given at 0, 4, and 8 hours compared to a single 150-mg drug dose given.
Rodin, “The Kiss” (545 x 800). Accessed at
Coral Snake (Close-Up)
Practicing sit-to-stand/sit-from-stand transfers using a variety of seating surfaces will better simulate a patient's home and community environment. Source:
Areas that are chronically excoriated can evolve into lichen simplex chronicus. Source: Atopic Dermatitis, Comprehensive Pediatric Hospital Medicine, 2e.
Summary of potential mechanisms by which H
Electronic configuration of the noble gas neon (Ne) shown in two versions of an energy diagram. While the horizontal orientation at right is useful in.
An adolescent with a peripherally inserted central venous catheter (PICC line) in the right upper extremity. Source: Pediatric Acute-Care Hospital, Meeting.
Illustration of ways regression lines can differ
(A). Systemic infusion of opioids. (B) Epidural infusion of opioids
A standard epidural order form.
FROM VICENZINO ET AL39 Source: Elbow and arm pain, Brukner & Khan’s Clinical Sports Medicine: Injuries, Volume 1, 5e Citation: Brukner P, Clarsen B, Cook.
Cutoff values used to determine low, medium, and high glycemic index foods. Also shown are sample foods for each index level. Source: Introduction to Basic.
Criteria used to determine breath types during mechanical ventilation
In this Tai Chi form, the participant shifts the body-weight toward one leg while moving the arms. Source: Exercise for Impaired Balance, Therapeutic Exercise:
Radiograph of a solitary plasmacytoma in the proximal femur of a 46-year-old man. Source: Chapter 5. Musculoskeletal Oncology, Current Diagnosis & Treatment.
The Yankauer-Gwathmey drop and vapor mask—similar to a kitchen strainer. (Reproduced from Flagg.34) Source: Anesthesia: Ketamine, Ether, and Halothane,
(Reproduced with permission from Amato AA, Russell JA
Staging system for gastric carcinoma
Paralysis or weakness of all extremities, plus all bulbar musculature: Corticobulbar and corticospinal tracts bilaterally Source: CEREBROVASCULAR DISEASES,
Adapted from Aronson L. Twelve tips for teaching reflection at all levels of medical education. Med Teach. 2011;33(3):200–205. Source: EDUCATING FOR PROFESSIONALISM,
Only three distinct stereoisomers of 1,3-dimethylcyclohexane are possible. These include a pair of enantiomers (bottom) and a single achiral stereoisomer.
B: Preparticipation examination
Longitudinal view of the proximal plantar fascia as it originates from the calcaneus (CALC). Source: Musculoskeletal Ultrasound, CURRENT Diagnosis & Treatment:
An example of stereoisomers that are achiral (not chiral)
Only three of a maximum possible four stereoisomers exists for the molecule shown. These include a pair of enantiomers and a single meso compound. Meso.
Assignment of configuration at a chirality center using the Cahn–Ingold–Prelog rules. Priority of substituents (1-4) is based on atomic number and the.
Estimated number of AIDS cases and AIDS deaths, United States, 1985–2011. (From CDC.) Source: Human Immunodeficiency Virus Disease: AIDS and Related Disorders,
Semilog graph of the rate of drug elimination in a one-compartment model. Source: One-Compartment Open Model: Intravenous Bolus Administration, Applied.
Cut-away view of a modern MRI machine. Please see text for description. Source: Overview of Diagnostic Modalities and Contrast Agents, Introduction to.
Equipment needed for central venous catheterization. A
The chiral proton pump inhibitor omeprazole is converted in the parietal cells of the stomach into an achiral sulphenamide intermediate. The sulphenamide.
Small bowel obstruction
Combat application tourniquet (CAT), by Composite Resources
A resonance hybrid structure for an amide bond is shown at top and is made up of two resonance forms. Resonance forms need not contribute equally to a.
Number of uninsured persons in the United States, 1980 to 2014 (U. S
The nomogram is also not useful if the time of ingestion is uncertain, if ingestion occurred more than 24 hours before presentation, or if repeated ingestion.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
General Principles for Writing Reaction Mechanisms
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
• Describe the three common mechanisms required for AS chemistry
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Introduction to Alkene Addition Reactions
Choosing the reagents for a substitution reaction
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Presentation transcript:

Reaction mechanism of the Michael addition reaction between a nucleophile and a polarized double bond. Source: Nucleophilic Substitution, Addition, and Elimination Reactions, The Organic Chemistry of Medicinal Agents Citation: Renslo A. The Organic Chemistry of Medicinal Agents; 2016 Available at: http://accesspharmacy.mhmedical.com/DownloadImage.aspx?image=/data/books/1731/renslo_ch06_fig-06-28.png&sec=116669535&BookID=1731&ChapterSecID=116669451&imagename= Accessed: November 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved