Pathophysiological alterations leading to neuronal injury during bacterial meningitis. BBB, blood-brain barrier; CBV, cerebral blood volume. (Redrawn, with permission, from Koedel U et al. Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect Dis. 2002;2:731.) Source: Infectious Diseases, Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e Citation: Hammer GD, McPhee SJ. Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e; 2013 Available at: https://accesspharmacy.mhmedical.com/DownloadImage.aspx?image=/data/Books/961/Ham007_Fig_04-08.png&sec=53627895&BookID=961&ChapterSecID=53555685&imagename= Accessed: November 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved