Volume 139, Issue 2, Pages (August 2010)

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Volume 139, Issue 2, Pages 483-490 (August 2010) Hepatitis B Surface Antigen Serum Levels Help to Distinguish Active From Inactive Hepatitis B Virus Genotype D Carriers  Maurizia Rossana Brunetto, Filippo Oliveri, Piero Colombatto, Francesco Moriconi, Pietro Ciccorossi, Barbara Coco, Veronica Romagnoli, Beatrice Cherubini, Giovanna Moscato, Anna Maria Maina, Daniela Cavallone, Ferruccio Bonino  Gastroenterology  Volume 139, Issue 2, Pages 483-490 (August 2010) DOI: 10.1053/j.gastro.2010.04.052 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Classification of the 209 HBeAg-negative/anti-HBe-positive HBV carriers according to HBV-DNA and ALT serum levels during the 1-year monthly monitoring. Gastroenterology 2010 139, 483-490DOI: (10.1053/j.gastro.2010.04.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Baseline HBsAg levels according to phase of infection (inactive vs active) and in active carriers (AC) according to HBV-DNA levels (persistently <20,000 IU/mL vs ≥20,000 IU/mL) and the presence and the stage of liver disease (chronic hepatitis vs cirrhosis). HBsAg levels were significantly different in the following: IC vs AC: P < .001; IC vs AC1: P < .001; AC1 vs AC2: P < .001. Gastroenterology 2010 139, 483-490DOI: (10.1053/j.gastro.2010.04.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Log10 HBV-DNA/HBsAg ratio by phase of infection and disease stage: IC vs AC: P < .001; IC vs AC1: P = NS; AC1 vs AC2: P < .001; chronic hepatitis vs cirrhotic patients: P = .023. Gastroenterology 2010 139, 483-490DOI: (10.1053/j.gastro.2010.04.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 4 Individual patient profiles during ALT flare: (A) HBsAg fluctuations during ALT flare (case A) and (B) HBsAg fluctuations during ALT flare (case B). Gastroenterology 2010 139, 483-490DOI: (10.1053/j.gastro.2010.04.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 5 (A) Receiver operating characteristic curve for HBsAg levels in AC vs IC: AUROC = 0.94, 95% CI: 0.905–0.975, P < .001. (B) ROC curve for HBsAg levels in AC2 vs IC: AUROC = 0.968, 95% CI: 0.942–0.993, P < .001. Gastroenterology 2010 139, 483-490DOI: (10.1053/j.gastro.2010.04.052) Copyright © 2010 AGA Institute Terms and Conditions

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