Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody– associated vasculitis Shen-Ju Gou, Jun Yuan, Min Chen, Feng Yu,

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Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody– associated vasculitis Shen-Ju Gou, Jun Yuan, Min Chen, Feng Yu, Ming-Hui Zhao Kidney International Volume 83, Issue 1, Pages 129-137 (January 2013) DOI: 10.1038/ki.2012.313 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Plasma levels of complement components in patients with active anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV), active lupus nephritis (LN), remission of AAV, and in normal controls. Horizontal solid lines indicated the mean level. (a) Plasma levels of Sc5b-9. (b) Plasma levels of C5a. (c) Plasma levels of C3a. (d) Plasma levels of Bb. (e) Plasma levels of properdin. (f) Plasma levels of C4d. Kidney International 2013 83, 129-137DOI: (10.1038/ki.2012.313) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 2 Changes of circulating complement levels in 20 anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV) patients with sequential plasma samples. (a) Plasma levels of Sc5b-9. (b) Plasma levels of C5a. (c) Plasma levels of C3a. (d) Plasma levels of Bb. (e) Plasma levels of properdin. (f) Plasma levels of C4d. Kidney International 2013 83, 129-137DOI: (10.1038/ki.2012.313) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 3 Plasma levels of C4, C2, and factor B in patients with active anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV), active lupus nephritis (LN), remission of AAV, and in normal controls. Horizontal solid lines indicated the mean level. (a) Plasma levels of C4. (b) Plasma levels of C2. (c) Plasma levels of factor B. Kidney International 2013 83, 129-137DOI: (10.1038/ki.2012.313) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 4 Association between circulating levels of Bb and clinicopathological parameters of patients with active anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). (a) Association between plasma levels of Bb and Birmingham Vasculitis Activity Scores (BVAS). (b) Association between plasma levels of Bb and erythrocyte sedimentation rate. (c) Association between plasma levels of Bb and the proportion of total crescents in renal specimens. (d) Association between plasma levels of Bb and the proportion of cellular crescents. Kidney International 2013 83, 129-137DOI: (10.1038/ki.2012.313) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 5 Immunohistochemistry staining for complement components Bb, C3d, and C5b-9 in renal specimens of patients with anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis. (a) Immunohistochemical staining of Bb in glomerulus of ANCA-associated vasculitis. (b) Immunohistochemical staining of C3d in glomerulus of ANCA-associated vasculitis. (c) Immunohistochemical staining of C5b-9 in glomerulus of ANCA-associated vasculitis. Kidney International 2013 83, 129-137DOI: (10.1038/ki.2012.313) Copyright © 2013 International Society of Nephrology Terms and Conditions