Robert C. Stanton, MD  American Journal of Kidney Diseases 

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Date of download: 7/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Decline in Estimated Glomerular Filtration Rate and.
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Presentation transcript:

Clinical Challenges in Diagnosis and Management of Diabetic Kidney Disease  Robert C. Stanton, MD  American Journal of Kidney Diseases  Volume 63, Issue 2, Pages S3-S21 (February 2014) DOI: 10.1053/j.ajkd.2013.10.050 Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Incidence counts and rates for the major causes of end-stage kidney disease. Diabetes mellitus has become the main cause for new cases of end-stage kidney disease. Reproduced from the US Renal Data System 2012 Annual Data Report.1 American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Prevalence counts and rates for the major causes of end-stage kidney disease. Diabetes mellitus has become the main cause for all cases of end-stage kidney disease. Reproduced from the US Renal Data System 2012 Annual Data Report.1 American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Prevalence counts of end-stage kidney disease by race. Although the white population has the highest number of cases, the prevalence rate is significantly higher in African Americans and Native Americans. Reproduced from the US Renal Data System 2012 Annual Data Report.1 American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Prevalence counts of end-stage kidney disease in the Hispanic population. The Hispanic population has a significantly higher prevalence than the non-Hispanic population. Data supplied by the US Renal Data System.1 American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 5 Rate of decline in glomerular filtration rate slows as mean arterial pressure is decreased. Adapted from Bakris et al70 with permission of National Kidney Foundation. American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 6 There is an increase in all-cause mortality in people with cardiovascular disease when systolic blood pressure is <115mm Hg. Reproduced with permission of American Medical Association from Cooper-DeHoff et al.68 American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 7 Increases in serum creatinine level of up to 30% from a baseline up to 3mg/dL within the first 4 months of starting angiotensin-converting enzyme inhibitor treatment correlated with slower rates of decline in renal function. Adapted from Bakris et al70 with permission of National Kidney Foundation. American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 8 In the RENAAL Study, the greater the initial decline in glomerular filtration rate, the slower the rate of progression of diabetic kidney disease. Reproduced with permission of Macmillan Publishers Ltd from Holtkamp et al.75 American Journal of Kidney Diseases 2014 63, S3-S21DOI: (10.1053/j.ajkd.2013.10.050) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions