Volume 390, Issue 10099, Pages 1048-1060 (September 2017) Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial  Dr Charlotte E Coles, PhD, Clare L Griffin, MSc, Anna M Kirby, MD, Jenny Titley, BSc, Rajiv K Agrawal, FRCR, Abdulla Alhasso, FRCR, Indrani S Bhattacharya, FRCR, Adrian M Brunt, FRCR, Laura Ciurlionis, MSc, Charlie Chan, DPhil, Ellen M Donovan, PhD, Marie A Emson, BSc, Adrian N Harnett, FRCR, Joanne S Haviland, MSc, Penelope Hopwood, MD, Monica L Jefford, MBA, Ronald Kaggwa, BSc, Elinor J Sawyer, PhD, Isabel Syndikus, MD, Yat M Tsang, MSc, Duncan A Wheatley, FRCR, Maggie Wilcox, John R Yarnold, FRCR, Judith M Bliss, MSc Wail Al Sarakbi, Sarah Barber, Gillian Barnett, Peter Bliss, John Dewar, David Eaton, Stephen Ebbs, Ian Ellis, Philip Evans, Emma Harris, Hayley James, Cliona Kirwan, Julie Kirk, Helen Mayles, Anne McIntyre, Judith Mills, Andrew Poynter, Elena Provenzano, Christine Rawlings, Mark Sculpher, Georges Sumo, Mark Sydenham, Andrew Tutt, Nicola Twyman, Karen Venables, Anna Winship, John Winstanley, Gordon Wishart, Alastair Thompson Dr Charlotte E Coles, PhD, Clare L Griffin, MSc, Anna M Kirby, MD, Jenny Titley, BSc, Rajiv K Agrawal, FRCR, Abdulla Alhasso, FRCR, Indrani S Bhattacharya, FRCR, Adrian M Brunt, FRCR, Laura Ciurlionis, MSc, Charlie Chan, DPhil, Ellen M Donovan, PhD, Marie A Emson, BSc, Adrian N Harnett, FRCR, Joanne S Haviland, MSc, Penelope Hopwood, MD, Monica L Jefford, MBA, Ronald Kaggwa, BSc, Elinor J Sawyer, PhD, Isabel Syndikus, MD, Yat M Tsang, MSc, Duncan A Wheatley, FRCR, Maggie Wilcox, John R Yarnold, FRCR, Judith M Bliss, MSc Wail Al Sarakbi, Sarah Barber, Gillian Barnett, Peter Bliss, John Dewar, David Eaton, Stephen Ebbs, Ian Ellis, Philip Evans, Emma Harris, Hayley James, Cliona Kirwan, Julie Kirk, Helen Mayles, Anne McIntyre, Judith Mills, Andrew Poynter, Elena Provenzano, Christine Rawlings, Mark Sculpher, Georges Sumo, Mark Sydenham, Andrew Tutt, Nicola Twyman, Karen Venables, Anna Winship, John Winstanley, Gordon Wishart, Alastair Thompson  The Lancet  Volume 390, Issue 10099, Pages 1048-1060 (September 2017) DOI: 10.1016/S0140-6736(17)31145-5 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Radiotherapy technique for partial-breast group Red shows the partial-breast planning target volume and blue shows the radiotherapy field arrangements shaped with multileaf collimators. See appendix p 9 for further details. The Lancet 2017 390, 1048-1060DOI: (10.1016/S0140-6736(17)31145-5) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Trial profile *Two patients withdrew consent for any of their data to be used in the analysis. The Lancet 2017 390, 1048-1060DOI: (10.1016/S0140-6736(17)31145-5) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Cumulative hazard of local relapse by treatment group HR=hazard ratio. The Lancet 2017 390, 1048-1060DOI: (10.1016/S0140-6736(17)31145-5) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions