Sangshin Park, DVM, MPH, PhD, Eun-Hee Lee, PhD, Younglim Kho, PhD 

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The association of asthma, total IgE, and blood lead and cadmium levels  Sangshin Park, DVM, MPH, PhD, Eun-Hee Lee, PhD, Younglim Kho, PhD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 6, Pages 1701-1703.e6 (December 2016) DOI: 10.1016/j.jaci.2016.04.030 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Total, direct, and indirect effects of blood lead levels on asthma through total IgE levels based on structural equation models, Korean National Health and Nutrition Examination Survey, 2010-2012. Adjusted for age, sex, occupation, education, family income, serum vitamin D [25(OH)D], smoking amount, the region of residence, and parental history of allergic diseases. Blood lead and total IgE levels were naturally log-transformed. Numbers represent ORs for a binary outcome (asthma) or a β coefficient for a continuous outcome (total IgE levels), 95% CIs, and P values. Indirect and total effects were 1.29 (95% CI, 1.06-1.57; P value, .013) and 2.52 (95% CI, 0.96-6.62; P value, .060), respectively. Percent mediated, the total effect explained by the mediation of total IgE level, was 27.4%. Journal of Allergy and Clinical Immunology 2016 138, 1701-1703.e6DOI: (10.1016/j.jaci.2016.04.030) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Venn diagram showing the number of study subjects (n = 5931), Korean National Health and Nutrition Examination Survey, 2010-2012. Each number is the number of subjects in each area. A total of 1979, 5912, and 1960 subjects were analyzed for the associations between heavy metal levels and IgE levels, between heavy metal levels and asthma, and between IgE levels and asthma. Journal of Allergy and Clinical Immunology 2016 138, 1701-1703.e6DOI: (10.1016/j.jaci.2016.04.030) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions