Image 3 Cytomorphologic criteria for circulating nonhematologic cells with benign features obtained by the isolation by size of epithelial tumor cell method.

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Image 3 Cytomorphologic criteria for circulating nonhematologic cells with benign features obtained by the isolation by size of epithelial tumor cell method. A, Lung epidermoid carcinoma. B, Sarcoidosis. C, Nodular hyperplasia of the thyroid. D, Thyroid adenoma. E, Parathyroid hyperplasia. F, Amygdalitis. G, Pneumonitis. H, Parathyroid adenoma (A–H, May-Grünwald-Giemsa, ×1,000). From: Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell MethodPromises and Pitfalls Am J Clin Pathol. 2015;135(1):146-156. doi:10.1309/AJCP9X8OZBEIQVVI Am J Clin Pathol | © American Society for Clinical Pathology

Image 3 Cytomorphologic criteria for circulating nonhematologic cells with benign features obtained by the isolation by size of epithelial tumor cell method. A, Lung epidermoid carcinoma. B, Sarcoidosis. C, Nodular hyperplasia of the thyroid. D, Thyroid adenoma. E, Parathyroid hyperplasia. F, Amygdalitis. G, Pneumonitis. H, Parathyroid adenoma (A–H, May-Grünwald-Giemsa, ×1,000). From: Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell MethodPromises and Pitfalls Am J Clin Pathol. 2015;135(1):146-156. doi:10.1309/AJCP9X8OZBEIQVVI Am J Clin Pathol | © American Society for Clinical Pathology

Image 2 Cytomorphologic criteria for circulating nonhematologic cells with uncertain malignant features obtained by the isolation by size of epithelial tumor cell method. A, Lung epidermoid carcinoma. B, Malignant mesothelioma. C, Metastatic large bowel carcinoma. D, Head and neck carcinoma. E and F, Thyroid adenoma. G and H, Parathyroid adenoma (A–H, May-Grünwald-Giemsa, ×1,000). From: Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell MethodPromises and Pitfalls Am J Clin Pathol. 2015;135(1):146-156. doi:10.1309/AJCP9X8OZBEIQVVI Am J Clin Pathol | © American Society for Clinical Pathology

Image 2 Cytomorphologic criteria for circulating nonhematologic cells with uncertain malignant features obtained by the isolation by size of epithelial tumor cell method. A, Lung epidermoid carcinoma. B, Malignant mesothelioma. C, Metastatic large bowel carcinoma. D, Head and neck carcinoma. E and F, Thyroid adenoma. G and H, Parathyroid adenoma (A–H, May-Grünwald-Giemsa, ×1,000). From: Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell MethodPromises and Pitfalls Am J Clin Pathol. 2015;135(1):146-156. doi:10.1309/AJCP9X8OZBEIQVVI Am J Clin Pathol | © American Society for Clinical Pathology

Image 1 Cytomorphologic criteria for circulating nonhematologic cells with malignant features (CNHC-MF) obtained by the isolation by size of epithelial tumor cell method. A, Esophageal adenocarcinoma. B, Head and neck carcinoma. C, Malignant mesothelioma. D, Lung adenocarcinoma. E and F, Thyroid adenoma. G and H, Parathyroid adenoma. Arrows, anisonucleosis; arrowhead, irregular nuclear borders and large nuclei; double arrows, 3-dimensional sheets; asterisks, cells satisfying the criteria for CNHC-MF (A–H, May-Grünwald-Giemsa, ×1,000). From: Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell MethodPromises and Pitfalls Am J Clin Pathol. 2015;135(1):146-156. doi:10.1309/AJCP9X8OZBEIQVVI Am J Clin Pathol | © American Society for Clinical Pathology

Image 1 Cytomorphologic criteria for circulating nonhematologic cells with malignant features (CNHC-MF) obtained by the isolation by size of epithelial tumor cell method. A, Esophageal adenocarcinoma. B, Head and neck carcinoma. C, Malignant mesothelioma. D, Lung adenocarcinoma. E and F, Thyroid adenoma. G and H, Parathyroid adenoma. Arrows, anisonucleosis; arrowhead, irregular nuclear borders and large nuclei; double arrows, 3-dimensional sheets; asterisks, cells satisfying the criteria for CNHC-MF (A–H, May-Grünwald-Giemsa, ×1,000). From: Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell MethodPromises and Pitfalls Am J Clin Pathol. 2015;135(1):146-156. doi:10.1309/AJCP9X8OZBEIQVVI Am J Clin Pathol | © American Society for Clinical Pathology

Image 4 Different numbers of circulating nonhematologic cells (CNHCs) observed in nonmalignant and malignant diseases. A and B, Isolated CNHCs or fewer than 10 CNHCs. Thyroid hyperplasia. C and D, Between 10 and 100 CNHCs. Thyroid adenoma. E and F, More than 100 CNHCs. Malignant mesothelioma (A, C, and E, May-Grünwald-Giemsa, ×200; B, D, and F, May-Grünwald-Giemsa, ×1,000). From: Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell MethodPromises and Pitfalls Am J Clin Pathol. 2015;135(1):146-156. doi:10.1309/AJCP9X8OZBEIQVVI Am J Clin Pathol | © American Society for Clinical Pathology