Parathyroid Hormone Christina Chan.

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Presentation transcript:

Parathyroid Hormone Christina Chan

Gland and Chemical Class Parathyroid Gland Polypeptide

Target Tissue and Source of Control bones and kidneys CHIEF CELLS produce PTH function: control concentration of calcium in blood

When Calcium concentration falls below normal... chief cells secrete PTH release of stored calcium from bone enhanced reabsorption of calcium in kidneys stimulation of calcitriol production at kidneys calcium important for nervous, muscular and skeletal system 1) chief cells produce and secrete PTH 2) stimulation of osteoclasts and inhibition of osteoblasts unlike thyroid gland, PT gland has no effect on metabolism

Hyper/Hypo-Secretion Hyperparathyroidism: PT gland produces too much PTH due to a tumor on PT gland Hypoparathyroidism: when PT gland produces too little PTH Hyper: 1. chronic fatigue, depression, bones hurt, osteoporosis 2. Decalcification of bone which leads to fractures (osteitis fibrosa cystica). Hypo: nerve depolarization → muscle cramps, random muscle spasms, twitches, and convulsions 2. Trousseau sign - Cuffing the arm leads to irreversible flexion of fingers. 3. Chvostek sign - Tapping the facial nerve branches at the lower margin of the jaw produces contractions of facial muscles.

Bibliography Bowen, R. "Parathyroid Hormone." Colorado State University. N.p., 28 Sept. 2003. Web. 11 Feb. 2014. <http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/thyroid/pth.html>. "Endocrine Hormones and Disorders." Union County College. N.p., 10 Feb. 2014. Web. 11 Feb. 2014. <http://faculty.ucc.edu/biology-potter/Endocrine%20hormones%20and%20disorders.htm>. "Normal Parathyroid Gland Function. How Parathyroid Glands Work." Parathyroid. Norman Parathyroid Center, n.d. Web. 11 Feb. 2014. <http://www.parathyroid.com/parathyroid-function.htm>. Rennert, Nancy J., ed. "PTH." MedlinePlus. A.D.A.M, 11 Dec. 2011. Web. 11 Feb. 2014. <http://www.nlm.nih.gov/medlineplus/ency/article/003690.htm>. Thompson, E. Gregory. "Parathyroid Hormone." Web MD. Healthwise, 10 Apr. 2010. Web. 11 Feb. 2014. <http://www.webmd.com/a-to-z-guides/parathyroid-hormone>.