Volume 66, Issue 5, Pages (November 2004)

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Volume 66, Issue 5, Pages 1766-1773 (November 2004) Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats Vicente E. Torres, William E. Sweeney, Xiaofang Wang, Q.I. Qian, Peter C. Harris, Philip Frost, Ellis D. Avner Kidney International Volume 66, Issue 5, Pages 1766-1773 (November 2004) DOI: 10.1111/j.1523-1755.2004.00952.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Epidermal growth factor receptor (EGFR) expression analyzed by Western analysis and immunolocalization. (A) Immunoblot of proteins isolated from wild-type and PCK kidneys showing a lower EGFR expression in the cystic kidney. (B) Localization, mostly basolateral, of EGFR in tubules and cysts from PCK kidney. Kidney International 2004 66, 1766-1773DOI: (10.1111/j.1523-1755.2004.00952.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Representative cross-sections (hematoxylin-eosin) of kidneys from control PCK rats (A, C, and E) and PCK rats treated with intraperitoneal EKI-785 (B) or EKB-569 (D and F). Kidneys (A to D) are from male animals, and kidneys (E and F) are from female animals. Kidney International 2004 66, 1766-1773DOI: (10.1111/j.1523-1755.2004.00952.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Renal levels of adenosine 3′,5′-cyclic monophosphate (cAMP) and vasopressin V2 receptor mRNA in male control PCK rats and rats treated intraperitoneally with EKI-785 or EKB-569. *Significant difference (P < 0.05) compared to control. Kidney International 2004 66, 1766-1773DOI: (10.1111/j.1523-1755.2004.00952.x) Copyright © 2004 International Society of Nephrology Terms and Conditions