Mastering the Chemical Language of Bacteria

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Presentation transcript:

Mastering the Chemical Language of Bacteria Warren R.J.D. Galloway, James T. Hodgkinson, Martin Welch, David R. Spring Chemistry & Biology Volume 16, Issue 9, Pages 913-914 (September 2009) DOI: 10.1016/j.chembiol.2009.09.006 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 An Outline of LasR-Mediated Quorum Sensing in P.aeruginosa Binding of OdDHL to the LasR receptor promotes receptor dimerization and the resultant homodimer complex binds target DNA to activate gene transcription. The chemical structure of OdDHL is given, together with OOHL, that acts via a different receptor protein. The structure of the nonnative TP-ligands developed by Muh et al. (2006b) are also shown. Chemistry & Biology 2009 16, 913-914DOI: (10.1016/j.chembiol.2009.09.006) Copyright © 2009 Elsevier Ltd Terms and Conditions