Includes Studies of Neurological Diseases & Personality

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Presentation transcript:

Includes Studies of Neurological Diseases & Personality Neurogenetics Science of the Effect of the Genetic Code and its Inheritance on the development & function of the Nervous System and Behaviour Includes Studies of Neurological Diseases & Personality by Timo Pohl

Neurological Disorders Neurodegenerative Diseases Schizophrenia – NOTCH 4 Zinc Finger Protein 804 A Alzheimer's Disease – APOE, PICALM ADHD – Genes involved in Dopamine Neurotransmission Multiple Sclerosis – DR15, DQ6 Tourette's Syndrome,Autism, Epilepsy, Mental Retardation etc... Parkinson's Disease – LRRK2, PARK2, PARK7 Huntington's Disease - HTT ALS – SOD1,ALS2

Methods of Research Statistical Analysis Recombinant DNA Logarithm of Odds (LOD) - used in combination with pedigrees Quantitative Trait Loci (QTL) - screening for specific gene markers Recombinant DNA Any mutated form of a gene – induced or randomly occuring Forward/backward genetics Pheno-genotype/geno-phenotype Animal Research The role of genes and its interactions in creatures with simple NS & smaller genomes but evolutionary conserved homologous genes Mice, Drosophila, C. elegans, Zebrafish Reverse genetics: Recombinant Gene > Observation Cannot completely model the complexity of the human body Human Research Volunteers with certain coditions & illnesses Sampling of CSF, Blood, Muscle Tissue > Gene Sequencing

Behavioral Neurogenetics Observation of Effect & Interaction of genes on Behaviour & Traits Usually complex polygenic interaction of variants of genes Cross-Species Conservation - Evolutionary Conserved Genes Higher Cognitive Function - Dopamine Gene Expr. > Motivation&Learning > Synaptic Plasticity > Faster Response Time Aggression Different Levels of Aggression throughout Animal Kingdom Dependent on Serotonin and its Metabolism Serotonin(5HT), 5HT Receptor, MAO, SERT MAO-A Deficient Dutch Family – displayed over-average aggressive behavior Alcohol Dependency ALDH1B,2 Polymorphism > decreased Alcohol Met. > Predisposition to Alcoholism

Current Research Rapidly expanding & growing field since Human Genome Project (HGP) succeeded in decoding the entire Human Genome in 2003 helps identifying, understanding Neurological Disorders Important for classification & possible treatment