Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605.

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Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 1. A partially pigmented 2-year-old lesion on the upper left side of our patient's back. The lesion measured 3 cm in diameter, was round and had an irregular contour and surface. It had a verrucous pigmented rim on its medial side that measured 6-8 mm, while the prominent exophytic erythematous part measured 2.1 × 2.2 cm. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 2. The pathological examination confirmed an epidermal nevus at the periphery of the lesion. H&E staining, ×50 magnification. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 3.a, b The epidermis showed bowenoid features with irregularly sized nuclei, a loss of polarity, dyskeratosis and mitotic figures. c Some sections from the periphery of the specimen showed multiple intraepidermal eddies of atypical cells or the Borst-Jadassohn phenomenon (arrow). © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 4. Sheets of poorly differentiated, atypical, pleomorphic keratinocytes migrated from the epidermis into hair follicles. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 5. Pathological examination proved a perivascular and perineural invasion. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 6. The tumour exhibited a maximal depth of 7 mm. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 7. After 6 weeks, the regional lymph nodes were palpable. The swelling was so extensive that it also infiltrated the surrounding subcutaneous tissue measuring 12 × 17 cm. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 8. Metastasis is visible in both lungs (a) and in the spinal cord (b) on a CT image and bone scan, respectively. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus Case Rep Dermatol 2013;5:272-282 - DOI:10.1159/000355605 Fig. 9. Metastasis is visible in the brain on MRI images. © 2013 S. Karger AG, Basel - CC BY-NC 3.0