Evaluation of the Efficacy and Safety of Direct Oral Anticoagulants in Japanese Patients—Analysis of Pharmaceuticals and Medical Devices Agency Data

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Evaluation of the Efficacy and Safety of Direct Oral Anticoagulants in Japanese Patients—Analysis of Pharmaceuticals and Medical Devices Agency Data Yasuo Terayama, MD Journal of Stroke and Cerebrovascular Diseases Volume 26, Issue 6, Pages 1171-1181 (June 2017) DOI: 10.1016/j.jstrokecerebrovasdis.2016.12.035 Copyright © 2017 National Stroke Association Terms and Conditions

Figure 1 Number of cerebrovascular events reported to the PMDA during 2014 among patients who received DTI and FXa. Abbreviations: DTI, direct thrombin inhibitors; FXa, factor Xa inhibitors; PMDA, Pharmaceuticals and Medical Devices Agency. Journal of Stroke and Cerebrovascular Diseases 2017 26, 1171-1181DOI: (10.1016/j.jstrokecerebrovasdis.2016.12.035) Copyright © 2017 National Stroke Association Terms and Conditions

Figure 2 Frequencies of hemorrhagic and ischemic events among patients prescribed DTI and FXa. Abbreviations: DTI, direct thrombin inhibitors; FXa, factor Xa inhibitors. Journal of Stroke and Cerebrovascular Diseases 2017 26, 1171-1181DOI: (10.1016/j.jstrokecerebrovasdis.2016.12.035) Copyright © 2017 National Stroke Association Terms and Conditions

Figure 3 Comparison of the types of hemorrhagic events between patients prescribed DTI and FXa. Abbreviations: DTI, direct thrombin inhibitors; FXa, factor Xa inhibitors. Journal of Stroke and Cerebrovascular Diseases 2017 26, 1171-1181DOI: (10.1016/j.jstrokecerebrovasdis.2016.12.035) Copyright © 2017 National Stroke Association Terms and Conditions

Figure 4 Comparison of types of ischemic events between patients prescribed DTI and FXa. Abbreviations: DTI, direct thrombin inhibitors; FXa, factor Xa inhibitors. Journal of Stroke and Cerebrovascular Diseases 2017 26, 1171-1181DOI: (10.1016/j.jstrokecerebrovasdis.2016.12.035) Copyright © 2017 National Stroke Association Terms and Conditions

Figure 5 The age distribution of subdural (epidural) hemorrhage and intracerebral hemorrhage among patients treated with DTI and FXa. Abbreviations: DTI, direct thrombin inhibitors; FXa, factor Xa inhibitors. Journal of Stroke and Cerebrovascular Diseases 2017 26, 1171-1181DOI: (10.1016/j.jstrokecerebrovasdis.2016.12.035) Copyright © 2017 National Stroke Association Terms and Conditions

Figure 6 Concomitant drugs among patients with hemorrhagic and ischemic events with full- and low-dose DOACs. Abbreviation: DOAC, direct oral anticoagulant. Journal of Stroke and Cerebrovascular Diseases 2017 26, 1171-1181DOI: (10.1016/j.jstrokecerebrovasdis.2016.12.035) Copyright © 2017 National Stroke Association Terms and Conditions

Figure 7 Proportions of patients treated with full or low doses of DOACs during 2014. Abbreviation: DOAC, direct oral anticoagulant. Journal of Stroke and Cerebrovascular Diseases 2017 26, 1171-1181DOI: (10.1016/j.jstrokecerebrovasdis.2016.12.035) Copyright © 2017 National Stroke Association Terms and Conditions