Switch to RAL-containing regimen ARV-trial.com Switch to RAL-containing regimen Canadian Study CHEER Montreal Study EASIER SWITCHMRK SPIRAL Switch ER 1

Canadian Study: Switch ENF to RAL Pilot, open-label study 35 adults on salvage therapy with enfuvirtide-based regimen and HIV-1 RNA < 50 c/mL Switch of enfuvirtide to RAL 400 mg bid, the remainder of the salvage regimen being unchanged. At the time of the switch: ENF had been administered for a median of 25 months HIV-1 RNA was < 50 c/mL for a median of 24 months Salvage regimen: 1 to 4 NRTIs, 1 NNRTI in 6 patients, 1 to 2 PIs Median follow-up of 7 months (range 1-13 months) 34/35 patients maintained HIV-1 RNA < 50 c/mL 1 single blip at 60 c/mL ENF-related injection site reactions resolved in all patients RAL was well tolerated Canadian Harris M, AIDS 2008;22:1224-6