Hyperimmune IV Immunoglobulin Treatment Ivan F.N. Hung, MD, Kelvin K.W. To, MD, Cheuk-Kwong Lee, MD, Kar-Lung Lee, MD, Wing-Wa Yan, MD, Kenny Chan, MD, Wai-Ming Chan, MD, Chun-Wai Ngai, MD, Kin-Ip Law, MD, Fu-Loi Chow, MD, Raymond Liu, MD, Kang-Yiu Lai, MD, Candy C.Y. Lau, PhD, Shao- Haei Liu, MD, Kwok-Hung Chan, PhD, Che-Kit Lin, MD, Kwok-Yung Yuen, MD  CHEST  Volume 144, Issue 2, Pages 464-473 (August 2013) DOI: 10.1378/chest.12-2907 Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 1 Recruitment flowchart of the 35 patients. H-IVIG = hyperimmune IV immunoglobulin; IVIG = IV immunoglobulin. CHEST 2013 144, 464-473DOI: (10.1378/chest.12-2907) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 2 Kaplan-Meier estimates of 22 patients who received treatment within 5 days of symptoms onset. See Figure 1 legend for expansion of abbreviations. CHEST 2013 144, 464-473DOI: (10.1378/chest.12-2907) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 3 Temporal changes of viral load and IL-6 level in treatment and control groups. See Figure 1 legend for expansion of abbreviations. CHEST 2013 144, 464-473DOI: (10.1378/chest.12-2907) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 4 Temporal changes of viral load and IL-10 level in treatment and control groups. See Figure 1 legend for expansion of abbreviations. CHEST 2013 144, 464-473DOI: (10.1378/chest.12-2907) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 5 Temporal changes of viral load and TNF-α level in treatment and control groups. TNF = tumor necrosis factor. See Figure 1 legend for expansion of other abbreviations. CHEST 2013 144, 464-473DOI: (10.1378/chest.12-2907) Copyright © 2013 The American College of Chest Physicians Terms and Conditions