Rob Corbett NCCN Christchurch Burkitt Lymphoma Rob Corbett NCCN Christchurch

Burkitt Lymphoma Non-Hodgkin lymphoma or Mature B cell lymphoma Very rapid growth! Diverse / multiofocal presentations 3 types: Endemic Sporadic Immune-deficiency Spread to BM and CNS Very sensitive to chemotherapy Endemic: EBV + malaria Found: Tropical Africa PNG / Solomons 30-50% of childhood cancers 6yrs >males Sites Abdomen Orbit/jaw Both Paraspinal

Burkitt Lymphoma Sporadic Both Endemic and Sporadic: Found Europe N Amercia Australasia Peak age sl older Marked male predominance Abdominal disease, then head and neck Both Endemic and Sporadic: Stage I/II 20% Stage III 65% Stage IV 15%

Burkitt Lymphoma – Patient Journey PNG 5yo male Ill for 3 weeks with abdominal distention and wt loss O/E Unwell uncomfortable Cachetic pale Abdomen “full” and tense without discreet masses Radiology US – hypoechoic masses CT Diagnosis Fine needle aspirate Sample fluid “starry sky” Staging CSF BMs

Burkitt Lymphoma – Patient Journey Supportive care vital Pain control Infection Nutrition Tumour lysis syndrome – critical Treatment – depends on resources

Patient Journey 12 month EFS Overall 61% Stage I 100% Stage II 85% Stage III 60% Stage IV 27%

Burkitt Lymphoma – Pacific Is