Presenter: dr. Robert Klesges Professor of Preventive Medicine

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Presentation transcript:

Tips on Writing a Competitive NIH Grant Proposal Friday, October 6, 2010 Presenter: dr. Robert Klesges Professor of Preventive Medicine University of Tennessee Health Science center and Member, Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital

Changes to grant applications (R01s) Resubmission = 1 page (down from 3) Specific Aim = 1 page (same) Research Strategy = 12 pages (down from 24) and is now in three categories (no more Significance, Previous Work, and Research Plan): Significance Innovation Approach

New review system Nine point “Overall impact” “High” (1 = Exceptional, 2 = Outstanding, 3= Excellent) “Medium” (4 = Very good, 5 = Good, 6 =Satisfactory) “Low” (7 = Fair, 8 = Marginal, 9 = Poor)

New review system (cont.) Overall impact = How funding is determined. Separate scores for: Significance Investigators Innovation Approach (the most important criteria) Environment Overall impact does not need to be the average of the five subcriteria.

Changes to review process Abbreviated application and abbreviated review. Almost all discussed applications are resubmissions (remember, we now only get one resubmission). We were specifically and repeatedly told that the criticism of “more information is needed” is NOT a valid criticism.

Reviews New reviews have separate scores for each area. Strengths and weaknesses are listed for the overall impact as well as each of the criteria. Strengths and weaknesses are listed in bullet format – a great format if you have an excellent reviewer and a horrible format if you don’t. We are reviewing more grant applications (e.g. 10-12) and reviewing many proposals out of our research areas.

Other criteria that aren’t part of the overall impact (with one exception) Protections for human subjects* Human subjects now can impact the overall impact score. Inclusion of women, minorities, and children* Vertebrate Animals* Biohazards* Resubmission Renewal Revision *Required in all applications and not part of the 13 page application

Additional Review Considerations Budget and Period of Support Select Agents Applications from Foreign Organizations Resource Sharing Plan (Not part of the 13 page application)

Components of good applications Liberal use of margins You can’t “cheat” and start the research strategy on the Specific Aims page Many good applications use the Specific Aims page to include the literature review Specific aims must include public impact statement. Most good applications make it easy for the reviewers to fill the template in (“The Significance of this application…”, “The innovativeness of this application…”, etc.)

Components of good applications Put what you use to put in the Significance in the Specific Aims Get RID of Previous Work for the most part. That is what the new Bio Sketch is for. New Bio Sketches are very important, no longer just pages to show qualifications. It establishes previous work in support of this particular study. Only include previous work if the data are truly preliminary work for the application.

Sections Specific Aims (has to be 1 page, put a lot of significance here) Significance – Keep it short as possible. Innovation – Keep it to one paragraph Approach – This is where the “meat” of the application is.

Approach Have half the space that we’ve previously had. Note there no longer IS a previous work section (but if you have data, you put it in this section). All other sections that we had in the previous Research Strategy section are present in the Approach section.

Sections you do NOT truncate Design Justification of Design Clear statement of independent and dependent variables Procedure (including a description of the facility, participants, measures, interventions). In short, include everything they need to evaluate the current application.

Sections you should truncate Data management (some place it in Human Subjects or use Appendices) Quality control/quality assurance (Human Subjects/Appendices) DSMP/DSMB (Move to Human Subjects) Time Line Statistical Power/Statistical Analysis (although this is still critical). Note: Chances are VERY high that a statistician will NOT review your grant.

Other issues Liberal use of figures, tables, etc. Do not spend a lot of space on measures, except for your primary outcome. Some applicants just had a table of measures. Gone are the days that we cut and paste lots of text from previous grant applications. Observation from study section: Avoid R21s (6 pgs.). Write it clearly and easy to understand. The quote from a NCI Program is more important than ever: “Assume all reviewers are idiots.”

Summary At the end of a five page letter, Mark Twain once said: “I’m sorry I wrote such a long letter but I didn’t have time to write a short one.”