The American Journal of Medicine

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The American Journal of Medicine Outcomes of Transcatheter and Surgical Aortic Valve Replacement in Patients on Maintenance Dialysis Fahad Alqahtani, MD, Sami Aljohani, MD, Khaled Boobes, MD, Elad Maor, MD, PhD, Assem Sherieh, MD, Charanjit S. Rihal, MD, David R. Holmes, MD, Mohamad Alkhouli, MD The American Journal of Medicine DOI: 10.1016/j.amjmed.2017.05.031 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Temporal trends of dialysis patients undergoing surgical (blue line) and transcatheter (red line) aortic valve replacement in the United States between 2005 and 2014. The American Journal of Medicine DOI: (10.1016/j.amjmed.2017.05.031) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 In-hospital mortality in propensity-matched patients on maintenance dialysis after surgical (SAVR) or transcatheter aortic valve replacement (TAVR). (A) In-hospital mortality in the overall TAVR versus SAVR groups. (B) In-hospital mortality in the transapical TAVR versus SAVR groups. (C) In-hospital mortality in the transfemoral TAVR versus SAVR groups. The American Journal of Medicine DOI: (10.1016/j.amjmed.2017.05.031) Copyright © 2017 Elsevier Inc. Terms and Conditions

Supplementary Figure 1 Patient selection flow diagram. NE = national estimates. The American Journal of Medicine DOI: (10.1016/j.amjmed.2017.05.031) Copyright © 2017 Elsevier Inc. Terms and Conditions

Supplementary Figure 2 Sensitivity analysis for required strength on an unmeasured confounder. Each line splits the area into 2: the upper right area represents all parameter combinations of an association between an unmeasured confounder to the treatment (surgical aortic valve replacement; y-axis) and the outcome (blood transfusion; x-axis) required to move the measured odds ratio to null. Conversely, the lower left corner represents all parameter combinations of an association between an unmeasured confounder to the treatment and outcome that would not move the measured odds ratio to null. HD = hemodialysis. The American Journal of Medicine DOI: (10.1016/j.amjmed.2017.05.031) Copyright © 2017 Elsevier Inc. Terms and Conditions

Supplementary Figure 3 Standardized differences between the transcatheter and the surgical aortic valve replacement groups before and after propensity matching. CABG = coronary artery bypass graft. The American Journal of Medicine DOI: (10.1016/j.amjmed.2017.05.031) Copyright © 2017 Elsevier Inc. Terms and Conditions