Laboratoire d'Automatique et de Génie des Procédés

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Presentation transcript:

Laboratoire d'Automatique et de Génie des Procédés LAGEP Laboratoire d'Automatique et de Génie des Procédés Université Claude Bernard Lyon 1 and CNRS UMR 5007

GEPHARM: Génie Pharmacotechnique New pharmaceutical dosage forms Design and development of drug delivery systems (nanoparticles, nanocapsules, nanoemulsions, liposomes etc..) Development of manufacturing processes Nano and microencapsulation Conventional forms (tablets, capsules…) Biopharmacy Oral, parenteral and topic (skin penetration and absorption control) administration Diagnostic tools Particules functionalisation and biomolecules association (protéines – virus) Preparation methods : emulsions step / precipitation Emusification processes : mechanical energy, ultra-sounds, high pressure homogeneisation, membranes processes

Revert immunosuppression Long lasting drug activity Different nanocarrier prototypes Increase solubility of drugs and protect genetic material Possibility of functionalization with specific ligands Possibility to chose the administration route Improve in vitro and in vivo stability Nano-immuno medicine : ongoing projects Vaccine Delivery Gemcitabine loaded LNC MDSC Revert immunosuppression Paclitaxel Retinoic acid Calcitriol Long lasting drug activity Melanoma (B16) expresses the telomerase reverse transcriptase TERT. The ACT for melanoma is composed of T cells targeting TERT. TERT-specific T cells were obtained from a mixed-leukocyte peptide culture set up with splenocytes obtained from vaccinated mice 1-Lollo et al. Polyarginine Nanocapsules as a Potential Oral Peptide Delivery Carrier.J Pharm Sci. 2017 2-Sasso et al., Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy. Biomaterials 2016 3-Lollo G et al. Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma. Int J Pharm. 2015

GEPHARM: Génie Pharmacotechnique BIOTOP platform Bioproduction, Freeze-drying Pharmaceutical dosage form Physico-chemistry platform Micrometrics, rheology, Interfacial studies… Scale-up platform IMTHERNAT : Imagerie Moléculaire et THERapeutique à base de Nanoparticules et/ou de Traceurs SPECT-CT, Imagerie Bioluminescence fluorescence Radiomarquage des NP ou cellules- Biodistribution des Nanoparticules 4