Spleen Enlargement on Follow-Up Evaluation: A Noninvasive Predictor of Complications of Portal Hypertension in Cirrhosis  Annalisa Berzigotti, Paola Zappoli, Donatella Magalotti, Carolina Tiani, Valentina Rossi, Marco Zoli  Clinical Gastroenterology and Hepatology  Volume 6, Issue 10, Pages 1129-1134 (October 2008) DOI: 10.1016/j.cgh.2008.05.004 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Spleen dimension on US follow-up evaluation in the studied population. As shown, spleen enlarged over time in cirrhotic patients (ANOVA, P < .0001). Clinical Gastroenterology and Hepatology 2008 6, 1129-1134DOI: (10.1016/j.cgh.2008.05.004) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 The actuarial probability of formation of varices at 5 years was higher in patients with increased spleen size at 1 year (grey line) vs those with stable spleen size (black line). Log-rank test, 8.47; P = .004. *Months of follow-up evaluation after the clinical, laboratory, and US assessment at 12 months. Clinical Gastroenterology and Hepatology 2008 6, 1129-1134DOI: (10.1016/j.cgh.2008.05.004) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 The actuarial probability of growth of varices at 5 years was higher in patients with increased spleen size at 1 year (grey line) vs those with stable spleen size (black line). Log-rank test, 3.42; P = .06. *Months of follow-up evaluation after the clinical, laboratory, and US assessment at 12 months. Clinical Gastroenterology and Hepatology 2008 6, 1129-1134DOI: (10.1016/j.cgh.2008.05.004) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 The actuarial probability of first clinical decompensation of cirrhosis at 5 years in patients with compensated disease at inclusion was higher in patients with increased spleen size at 1 year (grey line) vs patients with stable spleen size (black line) (log-rank test, 5.66; P = .017). *Months of follow-up evaluation after the clinical, laboratory, and US assessment at 12 months. Clinical Gastroenterology and Hepatology 2008 6, 1129-1134DOI: (10.1016/j.cgh.2008.05.004) Copyright © 2008 AGA Institute Terms and Conditions