Friedel–Crafts reaction

Slides:

Advertisements

Similar presentations

Electrophilic Substitution Reactions

Advertisements

AROMATIC COMPOUNDS By PUAN AZDUWIN BINTI KHASRI. Criteria for Aromaticity 1. A compound must have an uninterrupted cyclic cloud of electrons above and.

Organic Chemistry Reviews Chapter 15 Cindy Boulton March 29, 2009.

Organic Reactions Dr. M. Abd-Elhakeem Faculty of Biotechnology Organic Chemistry Chapter 3.

Friedel–Crafts Acylation Reactions The electrophile is an acylium ion.

WWU-Chemistry Aromatic Substitution Electrophilic.

Chapter 17 Reactions of Aromatic Compounds

1 Chapter 13 Unsaturated Hydrocarbons 13.7 Properties of Aromatic Compounds.

Friedel-Crafts Alkylation Carbon-carbon bonds to benzene can be created using a sufficiently electrophilic carbon based electrophile. To create the.

Electrophilic Attack.

Chapter 9 Second Half. Electrophilic aromatic substitution electrophile (E + ) reacts with an aromatic ring and substitutes for one of the hydrogens The.

Original slide prepared for the Free Radical Substitution AQA organic reaction mechanisms Click a box below to go to the mechanism Electrophilic Addition.

CHEMISTRY OF BENZENE: ELECTROPHILIC AROMATIC SUBSTITUTION Dr. Sheppard CHEM 2412 Summer 2015 Klein (2 nd ed.) sections: 19.1, 19.2, 19.3, 19.4, 19.5, 19.6,

1 Benzene and Aromatic Compounds Buckminsterfullerene—Is it Aromatic? The two most common elemental forms of carbon are diamond and graphite. Their physical.

Benzene is treated with a mixture of concentrated nitric acid and concentrated sulphuric acid at a temperature not exceeding 50°C. As temperature increases.

Benzene Reactions Dr AKM Shafiqul Islam School of Bioprocess Engineering University Malaysia Perlis.

Aromatic Compounds PPT 102 ORGANIC CHEMISTRY 1 SEM 1 (2012/2013)

Aromatic Substitution

1 Substitution Reactions of Benzene and Its Derivatives: Electrophilic Addition/Elimination Reactions. Benzene is aromatic: a cyclic conjugated compound.

16. Chemistry of Benzene: Electrophilic Aromatic Substitution

Edexcel organic reaction mechanisms

Benzene Part 1.

Chemsheets AS006 (Electron arrangement)

Limitations on Friedel-Crafts Alkylation

 Delocalised electrons are what makes benzene so stable and allow it to resist addition reactions.  Electron rich benzene rings are prone to attack.

CONTENTS Prior knowledge Structure of benzene Thermodynamic stability Delocalisation Electrophilic substitution Nitration Chlorination Friedel-Crafts reactions.

Reactions of benzene Benzene is electron rich. Electrophiles are electron pair acceptors. So electrophiles might be expected to add to benzene, saturating.

Aromatic Compounds Aromatic compound: a hydrocarbon that contains one or more benzene-like rings. arene: a term used to describe aromatic compounds. Ar-:

Factors affecting Nuecleophilic substitution reaction

Electrophilic Aromatic Substitution (EAS)Reactions Overall reaction.

Aromatic Compounds.

Criteria for Aromaticity 1. The system must be cyclic 2. The system must be planar (flat) 3. Each ring atom must be part of a completely extended pi system.

1 Aldehydes and Ketones. Carbonyl compounds The compounds occur widely in nature as intermediates in metabolism and biosynthesis They are also common.

Electrophilic Substitution Lab 1 Chemical reactions in which an electrophile displaces a group in a compound, typically but not always hydrogen.

WWU-Chemistry Aromatic Substitution Chapter 22. WWU-Chemistry Sections to skip!! Skip sections 22.1 (most), 22.3, 22.4, and 2.13 through Keep

Chapter 5-2. Chemistry of Benzene: Electrophilic Aromatic Substitution

1 Friedel-Crafts: Control Problems Multiple alkylations can occur because the first alkylation adds electron density and makes the ring more reactive:

AQA organic reaction mechanisms

Reactions of arenes. Benzene and bromine can react together in an electrophilic substitution reaction.

Mass Spectral Data of the Products from Unknowns A-D Chemistry 283g- Experiment 5 Electrophilic Aromatic Substitution: A Friedel-Craft Acylation Reaction.

16. Chemistry of Benzene: Electrophilic Aromatic Substitution

1 Figure 18.1 Five examples of electrophilic aromatic substitution.

Electrophilic Aromatic Substitution Dr. Marwa Eid 1.

Name the homologous series

A guide for A level students KNOCKHARDY PUBLISHING

AQA organic reaction mechanisms

When a benzene ring is a substituent, it is called a

Mechanisms L.O. To know the mechanisms involved in heterolytic, electrophilic substitution of a benzene ring. Homework: 1. Test Yourself Q11-15 inclusive.

4-nitrophenol 2,4,6 tribromophenol Excess Br2

Heterocyclic Chemistry

Organic and biochemistry

Reaction of Benzene and its Derivatives.

A guide for A level students KNOCKHARDY PUBLISHING

ARENES CONTENTS Prior knowledge Structure of benzene

Electrophilic Substitution Reactions of Benzene

Organic reaction mechanisms

(Aromatic hydrocarbons)

Examples of Carbocation Formation

Friedel–Crafts reaction

07 December 2018 Reactions of Benzene C4.2 Aromaticity.

Edexcel organic reaction mechanisms

Pyridine Is Aromatic.

Friedel-Crafts Acylation of Benzene

There are two major classes of organic chemicals aliphatic : straight or branched chain organic substances aromatic or arene: includes one or more ring.

Mechanism of Electrophilic Aromatic Substitution

Benzene and Aromatic Compounds

Pyridine Is Aromatic.

Presentation transcript:

Friedel–Crafts reaction

What is the reaction? Formation of C–C bond to aromatic ring Two types C–C bond forms Alkylation substitution with R e.g. CH3Cl Acylation substitution with R–CO e.g. CH3COCl

Alkylation Reagents and conditions Alkyl chloride, RCl Halogen carrier catalyst, e.g. AlCl3 Anhydrous conditions

Examples of alkylation Substitution with CH3Cl Substitution with C2H5Cl C–C bond forms

Acylation Reagents and conditions Alkyl chloride, RCOCl Halogen carrier catalyst, e.g. AlCl3 Anhydrous conditions

Examples of acylation Substitution with CH3COCl Substitution with C2H5COCI C–C bond forms