Volume 60, Issue 5, Pages 1087-1096 (November 2011) Prognostic Factors in Second-Line Treatment of Urothelial Cancers With Gemcitabine and Paclitaxel (German Association of Urological Oncology Trial AB20/99)  Günter Niegisch, Rolf Fimmers, Roswitha Siener, Su-In Park, Peter Albers  European Urology  Volume 60, Issue 5, Pages 1087-1096 (November 2011) DOI: 10.1016/j.eururo.2011.07.063 Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 1 Overall survival (OS) depending on risk factors: (A) Original prognostic model (hemoglobin [Hb] <10g/dl, presence of liver metastases, Eastern Cooperative Oncology Group [ECOG] performance status [PS] ≥1). Only two patients presented three risk factors, so no additional group was created for them. Karnofsky PS was converted to ECOG PS according to the proposal of Ma et al. [11]. (B) Modified prognostic model (Hb <12g/dl, presence of liver metastases, ECOG PS ≥1). Karnofsky PS was converted to ECOG PS according to the proposal of Ma et al. [11]. (C) Modified prognostic model (Hb <10g/dl, lymph node–only disease, ECOG PS ≥1). Karnofsky PS was converted to ECOG PS according to the proposal of Ma et al. [11]. CI=confidence interval. European Urology 2011 60, 1087-1096DOI: (10.1016/j.eururo.2011.07.063) Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 2 Overall survival (OS) depending on risk factors (RFs) and modality of treatment: (A) Overall survival of patients with prior adjuvant or neoadjuvant treatment depending on the risk factor model (hemoglobin [Hb] <10mg/dl, presence of liver metastases, Eastern Cooperative Oncology Group [ECOG] performance status [PS] ≥1). No patient presented more than two RFs. Karnofsky PS was converted to ECOG PS according to the proposal of Ma et al. [11]. (B) Overall survival of patients with cisplatin failure prior treatment of metastatic disease depending on the risk factor model (Hb <10mg/dl, presence of liver metastases, ECOG PS ≥1). Only two patients presented three RFs, so no additional group was created for them. Karnofsky PS was converted to ECOG PS according to the proposal of Ma et al. [11]. (C) Overall survival of patients with early progression following the suggestion of Sonpavde et al. [14] depending on the risk factor model (Hb <10mg/dl, presence of liver metastases, ECOG PS ≥1). Only two patients presented three RFs, so no additional group was created for them. Karnofsky PS was converted to ECOG PS according to the proposal of Ma et al. [11]. CI=confidence interval. European Urology 2011 60, 1087-1096DOI: (10.1016/j.eururo.2011.07.063) Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 3 Accuracy of the prognostic model identifying patient subgroups: (A) Receiver operating characteristics (ROC) analysis of the original prognostic model and the modified prognostic model (hemoglobin [Hb] cut-off 12mg/dl) identifying patients with a poor overall survival [OS] (≤4.5 mo). Area under the curve (AUC)original=0.660, p=0.023; AUCmodified=0.708, p=0.003. (B) ROC analysis of the original prognostic model and the modified prognostic model (Hb cut-off 12mg/dl) identifying patients with a favorable OS (≥6.9 mo). AUCoriginal=0.634, p=0.036; AUCmodified=0.669, p=0.008. European Urology 2011 60, 1087-1096DOI: (10.1016/j.eururo.2011.07.063) Copyright © 2011 European Association of Urology Terms and Conditions