Antibodies to Collagen in Patients with Idiopathic Pulmonary Fibrosis George Nakos, M.D., Alex Adams, R.R.T., Nikos Andriopoulos, M.D.  CHEST  Volume 103, Issue 4, Pages 1051-1058 (April 1993) DOI: 10.1378/chest.103.4.1051 Copyright © 1993 The American College of Chest Physicians Terms and Conditions

Figure 1 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibody activity against native collagen type I, II, III and IV (r = –0.84, p<0.001). CHEST 1993 103, 1051-1058DOI: (10.1378/chest.103.4.1051) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

Figure 2 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibody activity against collagen chains type α1 + α1(I), α1(II) and α1(III) (r = –0.75, p<0.01). CHEST 1993 103, 1051-1058DOI: (10.1378/chest.103.4.1051) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

Figure 3 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibody activity against native or collagen chain type I (r = –0.57, p<0.05). CHEST 1993 103, 1051-1058DOI: (10.1378/chest.103.4.1051) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

Figure 4 Correlation between duration (months) of the disease and the higher titer in each patient (–log2) of antibodies activity against native or collagen chain type III (r = –0.8, p<0.001). CHEST 1993 103, 1051-1058DOI: (10.1378/chest.103.4.1051) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

Figure 5 Correlation between number of types of positive anticollagen antibodies in each patient and the median value (–log2) of antibodies activity (r = 0.91, p<0.01). CHEST 1993 103, 1051-1058DOI: (10.1378/chest.103.4.1051) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

Figure 6 Correlation between duration (months) of the disease and factor of activity (factor of activity = median value of anticollagen antibodies titer • number of collagen types with positive anticollagen antibodies [r = –0.87, p<0.001]). CHEST 1993 103, 1051-1058DOI: (10.1378/chest.103.4.1051) Copyright © 1993 The American College of Chest Physicians Terms and Conditions

Figure 7 Titers of anticollagen antibodies in a representative sample of serum from patient with IPF. The sample was chromatographed on a Sephadex G-200 column. CHEST 1993 103, 1051-1058DOI: (10.1378/chest.103.4.1051) Copyright © 1993 The American College of Chest Physicians Terms and Conditions