Engineered antibodies: A new tool for use in diabetes research Carolyn J. Padoa, Nigel J. Crowther  Diabetes Research and Clinical Practice  Volume 74, Issue 2, Pages S51-S62 (November 2006) DOI: 10.1016/j.diabres.2006.06.033 Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Structure of an IgG molecule (adapted from Kim et al. [92]). Diabetes Research and Clinical Practice 2006 74, S51-S62DOI: (10.1016/j.diabres.2006.06.033) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 A schematic representation of the genes coding for antibodies (adapted from Milstein [6]). Diabetes Research and Clinical Practice 2006 74, S51-S62DOI: (10.1016/j.diabres.2006.06.033) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Heavy chain gene rearrangement and alternative forms of splicing of precursor RNA (adapted from Milstein [6]). Diabetes Research and Clinical Practice 2006 74, S51-S62DOI: (10.1016/j.diabres.2006.06.033) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Schematic representation of recombinant antibody constructs (adapted from Kim et al. [92]). Diabetes Research and Clinical Practice 2006 74, S51-S62DOI: (10.1016/j.diabres.2006.06.033) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Generation of antibodies by phage technology (adapted from Marks et al. [93]). Diabetes Research and Clinical Practice 2006 74, S51-S62DOI: (10.1016/j.diabres.2006.06.033) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions