B. In the actual case in which the ACh receptor-channel is permeable to both Na+ and K+, experimental results show that the end-plate current reverses.

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B. In the actual case in which the ACh receptor-channel is permeable to both Na+ and K+, experimental results show that the end-plate current reverses at 0 mV because the ion channel allows Na+ and K+ to move into and out of the cell simultaneously (see Box 9–1). The net current is the sum of the Na+ and K+ fluxes through the end-plate channels. At the reversal potential (EEPSP) the inward Na+ flux is balanced by an outward K+ flux so that no net charge flows. Source: Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: http://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/1049/kan_ch9_f007.png&sec=59140772&BookID=1049&ChapterSecID=59138633&imagename= Accessed: October 07, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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