RH Odell, MD, PhD1, PM Carney, MD2, RE Sorgnard, PhD3 THE COMBINATION ELECTROCHEMICAL BLOCK (CEB) IN THE TREATMENT OF PERIPHERAL NEUROPATHY: PRELIMINARY RESULTS RH Odell, MD, PhD1, PM Carney, MD2, RE Sorgnard, PhD3 The Challenge: Neuropathies are major causes of morbidity, especially in our aging population. Available treatment options offer limited efficacy and significant side effects.   Electronic signal treatment (EST) Computer controlled, exogenously delivered specific-parameter digital ultra-high definition signal electroanalgesia Wide variation of both AM and FM signals including harmonic resonance frequencies are delivered with automatic, varying changes in signal dwell times, repetition rates and dosages (amplitudes) of the electronic digital signals Known salutary physiologic benefits, including anti-inflammatory, immune system and nerve cell healing effects A New Solution: Combining EST with chemical nerve blocks (CNB), termed the Combination Electrochemical Block CEB ENBs achieve a nerve cell depolarization block, while CNBs produce a hyperpolarization block It is hypothesized that the local nerve membrane polarization state alternates between hyperpolarization and depolarization depending upon differential local conditions along the (macro) sized axon. Both states block neuronal transmission while the cell is able to begin healing. Otherwise, ENBs and CNBs work on nerve cells in almost exactly the same way They work synergistically with minimal (easily avoided) side effects Primary Mechanism of Action: EST/CEB effects on cAMP In neuropathy & other disease states, measured lower than normal levels of cAMP is well known. cAMP directs all cell specific activity, and treatments which return cAMP to “normal” appear to have curative effects. EST via sustained depolarization is known to increase cAMP production up to normal levels.4 EST and the CEB thus normalize cell activity through this primary mechanism and numerous other mechanisms described elsewhere5,6. Study design: Prospective, nonrandomized, pilot study of 27 patients with four different kinds of neuropathies (diabetic, idiopathic, chemotherapy induced, traumatic). VAS and Peripheral Neuropathy Functional Index (PNFI) were used as endpoints. Results: Type Number Average CEB Pain Decreased No Pain Decrease % Change in % Change in PNFI Diabetic Peripheral Neuropathy 11 12.4 9 (82%) 2 (18%) 53% decrease 44% functional improvement Idiopathic peripheral neuropathy 7 10.7 6 (86%) 1 (14%) 56% decrease 36% functional improvement Drug induced peripheral neuropathy (Chemotherapy) 5 12.6 5 (100%) 71% decrease 47% functional improvement Post traumatic peripheral neuropathy 4 13.5 3 (75%) 1 (25%) 40% decrease 35% functional improvement 85% of patients exhibited improvement in pain, defined as at least a 25% decrease in VAS. Benefits of CEB were realized in all categories of neuropathies. Neuropathy patients showed marked symptom and motor function improvement with this safe and effective technology. Conclusions : CEBs have demonstrated effectiveness for the treatment of various neuropathies and chronic inflammatory pain conditions. CEBs appear to treat underlying causes of neuropathies CEBs appear to aid in reversing sensory and motor pathophysiology. These outcomes are exciting since there are limited treatment alternatives. CEBs offer the promise of treating difficult neuropathic pain conditions & deserve further study; a large multicenter study is in planning stages. 1Las Vegas, NV - Contact Dr. Odell at 702-521-9542 or drodell46@nvneuropathy.com  2Elkhart, Indiana  3Morhea Technologies, Las Vegas, NV  4Knedlitscheck G, et al. Cyclic AMP response in cells exposed to electric fields of different frequencies and intensities. Radiation Environmental Biophysics. 1994. 32:1-7.) 5Odell, Sorgnard. Anti-Inflammatory Effects of Electronic Signal Treatment; Pain Physician 2008; 11:891-907 (Nov/Dec edition) 6Odell, Sorgnard. New Device Combines Electrical Currents and Local Anesthetic for Pain Management; Practical Pain Management (2011) 11 (6): 52-68