The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals Maartje Verschuur, Annemarie.

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The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals Maartje Verschuur, Annemarie Jellema, Else M. Bladbjerg, Edith J. M. Feskens, Ronald P. Mensink, Lars Møller, Hans L. Vos, Moniek P.M. de Maat Atherosclerosis Volume 181, Issue 2, Pages 275-284 (August 2005) DOI: 10.1016/j.atherosclerosis.2005.01.036 Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 The promoter region of the PAI-1 gene. The −844A/G and the −675(4G/5G) variations and the locations of the haplotype-specific PCR primers are shown. The bottom part shows the fragments formed after digestion of the PCR products with XhoI. Atherosclerosis 2005 181, 275-284DOI: (10.1016/j.atherosclerosis.2005.01.036) Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 PAI-1 antigen levels of the haplotype combinations in the overall MORGEN sample (A) and in BMI Quartiles of the MORGEN sample (B). Bars represent the geometric mean (±S.D.) of the PAI-1 antigen levels expressed as a percentage of the geometric mean of the overall population, for each haplotype combination separately. Relative geometric means and number of subjects are indicated. Rare haplotype combinations are not shown, their relative PAI-1 antigen levels are: Quartile 2: (A-5G/A-5G: 148.9 (n=1)), Quartile 3: (A-4G/G-4G: 92.3 (n=1)) and (G-4G/G-5G: 163.1 (±55.7) (n=2)), Quartile 4: (G-4G/G-4G: 184.1 (n=1)) and (A-5G/A-5G: 227.7 (n=1)). Atherosclerosis 2005 181, 275-284DOI: (10.1016/j.atherosclerosis.2005.01.036) Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 PAI-1 antigen levels of the haplotype combinations in the overall Glostrup population (A) and in BMI Quartiles of the Glostrup population (B). Bars represent the geometric mean (±S.D.) of the PAI-1 antigen levels expressed as a percentage of the geometric mean of the overall population, for each haplotype combination separately. Relative geometric means and number of subjects are indicated. Rare haplotype combinations are not shown, their relative PAI-1 antigen levels are: Quartile 1: (A-4G/G-4G: 28.6 (±6.5) (n=2)), Quartile 3: (A-4G/G-4G: 82.3 (±18.1) (n=3)) and (A-5G/A-5G: 175.7 (n=1)), Quartile 4: (A-5G/A-5G: 529.1 (n=1)). Atherosclerosis 2005 181, 275-284DOI: (10.1016/j.atherosclerosis.2005.01.036) Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions