Diagnostic Solution – MMPA Panel Discussion To change this title, go to Notes Master 4/11/2018 Diagnostic Solution – MMPA Panel Discussion Dr. Ayaskant Pany

Q 2 LAB Pretoria, South Africa Established in 1999; CAP Accredited since 1999; First CAP accredited lab on the African continent; Only CAP accredited lab in South Africa. New facility inaugurated in Q4 2011. CAP15189 Accredited – First time successful – Oct 2014; Surveillance assessment 1 – completed Sep 2015. Certifications – CDC Lipids Certification; NGSP, Level 1 Number of employees: 47 + support functions Full Service laboratory facility services: Pre-analytical (Sample accessioning) Analytical (Safety and Esoteric) Project Services (Project management) Specimen Management and Storage (Ambient and Frozen) Clinic supplies (Kit building) Logistics Support

A range of scientific methodologies Central Labs 4/11/2018 Our broad range of capabilities support scientific advancement through multiple assays and tests. Our constantly expanding test menu includes more than 400 tests and assays, with capabilities in a full range of laboratory science disciplines, methods, instruments and therapeutic targets.

Spotlight on Tuberculosis A Full Array of Research Based TB Testing Capabilities ‘ONE STOP SHOP’ The Q2 Advantage in TB Testing Smear—conventional ZN and Fluorescent staining Culture, Identification, and Susceptibility (1st and 2nd line) – BD MGIT™ system as well as on LJ medium. HAINs assays - Genotypic drug resistance and Speciation. GeneXpert® system QuantiFERON®- TB Gold test Advanced immunological assays, e.g., ELISPOT MIC determination and New drug susceptibility Client specific ‘customized’ assays. All TB related testing in a single facility State-of-the-art biosafety labs Dedicated BSL3 level lab for all TB isolation

Tuberculosis Visit Schedule

Q2 Tailored Solution One-size does not fit-all Focused on the 4 high risk disease areas as agreed HIV TB Hypertension Diabetes We reviewed the requirements outlined in the NDoH guidelines for each therapeutic area and converted it into a structured protocol schedule which would be used to set up the Sibanye dedicated database. The below guidelines were used and testing applied accordingly TB investigations Reference – National TB management 2014 Guidelines; Released by the Department of Health; Compiled by - TB DOTS Strategy Coordination, National Department of Health. HIV investigations Reference - THE SOUTH AFRICAN ANTIRETROVIRAL TREATMENT GUIDELINES, 2013 - Released by the Department of Health. VERSION 14 March 2013 Diabetes investigations Reference - The 2012 SEMDSA Guideline for the Management of Type 2 Diabetes (Revised); JEMDSA 2012 Volume 17 Number 2 (Supplement 1) Page S1-S95 www.jemdsa.co.za Hypertension investigations Reference – South African hypertension practice guideline 2014; CARDIOVASCULAR JOURNAL OF AFRICA • Volume 25, No 6, November/December 2014. www.cvja.co.za General Reference - PRIMARY CARE 101 GUIDELINE 2013/14; Commissioned and published by: The National Department of Health Private Bag x828 Pretoria 0001. Developed by the University of Cape Town Lung Institute for the NDoH.

HIV Testing Schedule

Q2 Solutions patient-centric services To change this title, go to Notes Master 4/11/2018 Services, assay, and technology that put the patient first Sibanye Mine Clinic Sample collection Client dedicated database Shipment to Q2 testing Lab (Pretoria) Result reporting Sample management Project Manager TESTING: Diabetes, Hypertension, HIV, TB Other analytical tests