Infusion of Hi-Xen reduces the iAUCs for gastric emptying and postprandial glucose levels in humans with NGT, IGT, and T2DM. Infusion of Hi-Xen reduces.

Slides:

Advertisements

Similar presentations

Pramlintide – An analog of amylin that overcomes the tendency of human amylin to: Aggregate, form insoluble particles Adhere to surfaces – Pharmacokinetic.

Advertisements

Yunoki K et al. Atherosclerosis 2011 Epub Apr 22.

Thin-layer chromatography analysis of [3H]-labeled lipid fraction of the small intestine. Thin-layer chromatography analysis of [3H]-labeled lipid fraction.

SP receptor neurokinin 1 receptor (NK1R) is expressed in adipocytes and preadipocytes, and SP interferes with differentiation. 3T3-L1 preadipocytes were.

Anesthes. 2008;108(3): doi: /ALN.0b013e Figure Legend:

Glucagon-Like Peptide-1 Receptor (GLP-1R) Agonists and Dipeptidyl Peptidase-4 (DPP-4) Inhibitors: How Do They Exert Their Metabolic Actions?

Morning blood pressure surge (A), HR increase in the morning (B), cfPWV (C), sympathetic BRS (D), and cardiovagal BRS (E) in elderly hypertensive subjects.

PI 3-kinase inhibition has no effect on ANG II induced extracellular recognition kinase (ERK) 1/2 activation. PI 3-kinase inhibition has no effect on ANG.

Lipid hydroperoxide levels (μM) in hepatic tissue lyaste after 1 and 5 h of reperfusion after 60 min of ischemia. Lipid hydroperoxide levels (μM) in hepatic.

A: mean left ventricular torsion at end systole in 7 animals with increasing stenosis of an extracorporeal shunt to the LAD coronary artery. A: mean left.

Prednisone decreases podocyte apoptosis in experimental FSGS

Fig. 1. Intravenous glucose infusion rates during an isoglycemic intravenous glucose infusion (IIGI) study in subjects with (A) normal glucose tolerance.

Organic solute transporter (OSTα-OSTβ) expression in human control livers and patients with stage III and IV primary biliary cirrhosis. Organic solute.

Hierarchical clustering of DEGs in Shp−/− mice, chronic hepatitis C cirrhosis, and NASH. A: unsupervised hierarchical clustering of genes common to the.

Summary of the effects selective transection of pudendal nerve branches, in different orders, on cystometric parameters (each bar, n = 3; values are means.

Records of body temperature (A) and locomotor activity (B) of a flying squirrel maintained under a 24-h light-dark cycle with 14 h of light and 10 h of.

Net metabolic rate of walking at 1. 5 m/s vs

Effect of N-WASp glutathione-S-transferase (GST) fusion proteins on force in tracheal muscle strips stimulated with 10−5 M ACh under isometric conditions.

Plasma insulin concentrations (A) and insulin secretion rates (B) in response to molar increments of plasma glucose concentration during the graded glucose.

Behavioral dysfunction is observed in immunodeficient mice.

Fig. 2. Changes in the plasma glucose and NEFA levels

Arterioscler Thromb Vasc Biol

Volume 83, Issue 5, Pages (May 2013)

Figure 2 Expression of complement activation products in renal samples

Clinical Nutrition Experimental

Insulin and glucagon secretion: nondiabetic and diabetic subjects.

Glucose homeostasis: roles of insulin, glucagon, amylin, and GLP-1.

Marzieh Salehi, Amalia Gastaldelli, David A. D'Alessio

Dandan Wang et al. BTS 2018;3: Down-Regulation of miR-24 in Response to Insulin Infusion in Human Plasma Human plasma insulin (A), glucose (B),

GLP-1 Agonists and DPP-4 Inhibitors How do they work?

Volume 130, Issue 1, Pages (January 2006)

Volume 83, Issue 5, Pages (May 2013)

Improvement of insulin sensitivity by treatment of the annexin A1 receptor agonist in HFD mice. Improvement of insulin sensitivity by treatment of the.

(A) T2DM: serum glucose levels during glucose tolerance test (n=6 per group). (A) T2DM: serum glucose levels during glucose tolerance test (n=6 per group).

Comparison of triglycerides AUC 480’ between IGT+reduced FPIS group, IGT+preserved FPIS group, and IGT+reduced FPIS+reduced FPIS and FPIS restitution with.

Mineral content analysis by SEM-EDX.

63-year-old patient with right hemiparesis.

A–L: Xenin-25 amplifies the effects of GIP on plasma insulin, C-peptide, and glucose levels and ISRs in humans with NGT and IGT but not T2DM. A–L: Xenin-25.

Hyperinsulinemic-euglycemic clamp–derived insulin sensitivity (glucose disposal), model-derived insulin secretion parameters (sensitivity first-phase insulin.

A–F: Xenin-25 amplifies the insulin secretory response to GIP in humans with NGT and IGT but not T2DM. A–F: Xenin-25 amplifies the insulin secretory response.

A and B: Plasma levels of IR-GIP and xenin-25 during GGIs

The development of plasma (p-)C-peptide responses to an intravenous glucose (0.5 g glucose/kg body wt) and glucagon (1 mg) infusion test up to 5–7 years.

Plasma glucose (A) and glucose specific activity (B) during euglycemic clamp experiments. Plasma glucose (A) and glucose specific activity (B) during euglycemic.

Fig. 2. Immunostaining for ClC-5 in isolated hog gastric mucosa

Effect of PIs on insulin release by downstream insulin secretogogues.

Arterial plasma glucose level and peripheral GIR in conscious dogs during the basal (−40 to 0 min) and experimental (0–240 min) periods treated with vehicle.

FMD and PWV of patients with diabetes with (T2DM-SCT) or without (T2DM) SCT and of healthy individuals with (SCT) or without (CONT) SCT. FMD measured at.

A: Insulin-stimulated total, oxidative, and nonoxidative glucose disposal in subjects with NGT (open bars), IFG (dotted bars), IGT (striped bar), IFG/IGT.

Insulin secretion/insulin resistance (disposition) index (ΔINS/ΔGLU ÷ IR) in subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT),

Left columns: Plasma glucose and serum insulin concentrations, circulating TF-PCA, and FVIIa activity before and during 24 h of selective hyperglycemia.

Plasma growth hormone concentrations during a 65-min infusion of acyl ghrelin at 0.3, 0.9, or 1.5 nmol/kg/h, or saline. Plasma growth hormone concentrations.

The effect of sulfonylurea (glibenclamide = glyburide) and metformin therapy on the plasma HbA1c concentration in newly diagnosed T2DM subjects in UKPDS.

Effect of 4 weeks of an intensive exercise program on vaspin serum concentrations in normal glucose tolerant (NGT) individuals and patients with IGT or.

Arterial and portal plasma glucagon levels and the portal-arterial (P-A) glucagon gradient in the control period (−40 to 0 min) and after administration.

Caloric intake in lean and obese Zucker rats in response to systemic infusion of glucose alone (HG-HI protocol) or glucose with insulin (EuG-HI protocol).

Baseline and follow-up values for HbA1c, WBISI, IGI, and ODI in NGT subjects divided according to development of IGT at follow-up (progressors [dark green.

Mean (±SE) plasma glucose concentrations before, during, and after infusions of octreotide (with growth hormone) with saline (•), with insulin replacement.

Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance. Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance.

Food intake in response to central infusion of glucose (squares) or insulin (triangles) and in response to successive central infusion of insulin, insulin.

Pioglitazone administration acutely inhibits insulin secretion and increases insulin clearance in Wistar rats. Pioglitazone administration acutely inhibits.

Effects of vinegar (□) and placebo (⧫) on plasma glucose (A–C) and insulin (D–F) responses after a standard meal in control subjects, insulin-resistant.

Graph showing percentage of total patients with PTD or IGT that would be detected in each category of FBG if an oral glucose tolerance test were performed.

Elimination of dendritic spines per 2 d.

Bar graph shows the preventive effect of UV on the development of vasospasm for different irradiation time periods. Bar graph shows the preventive effect.

Plasma glucose (A), serum insulin (B), serum C peptide (C) and plasma GLP-1 level (D) during the 2-hour OGTT among subjects with normal glucose tolerance.

Differentiation of common pediatric brain tumors by quantitative 1H-MR spectroscopy. Differentiation of common pediatric brain tumors by quantitative 1H-MR.

Doses of trial medication in the liraglutide groups (A) and in the placebo groups (B). Doses of trial medication in the liraglutide groups (A) and in the.

Bar graph illustrating the rate of leak detection by CTM and MRM

Comparison of sympathetic activity, endothelial function and baroreflex sensitivity between differing metabolic risk categories (n=54). Comparison of sympathetic.

A: Diet-specific postprandial responses to glucose and NEFA levels.

Presentation transcript:

Infusion of Hi-Xen reduces the iAUCs for gastric emptying and postprandial glucose levels in humans with NGT, IGT, and T2DM. Infusion of Hi-Xen reduces the iAUCs for gastric emptying and postprandial glucose levels in humans with NGT, IGT, and T2DM. The iAUCs and ratio of the iAUCs with infusions of Alb (open bars), Lo-Xen (hatched bars), and Hi-Xen (solid bars) from Fig. 2 were calculated for each individual for the indicated time frame following Boost Plus ingestion. Values represent group means ± SE for plasma ACM (from 0–240 min; A–C), plasma glucose (from 0–120 min; D–F), ISRs (from 0–120 min; G–I), and the ratios of the glucose and ISR iAUCs (from 0–120 min; J–L). Data for subjects with NGT (A, D, G, J), IGT (B, E, H, K), and T2DM (C, F, I, L) are shown. In K, P = 0.05 is for the 1-way ANOVA comparing the means between all 3 groups. Sara Chowdhury et al. Am J Physiol Gastrointest Liver Physiol 2014;306:G301-G309 ©2014 by American Physiological Society