Thomas M. Williams The Journal of Molecular Diagnostics

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Presentation transcript:

Human Leukocyte Antigen Gene Polymorphism and the Histocompatibility Laboratory Thomas M. Williams The Journal of Molecular Diagnostics Volume 3, Issue 3, Pages 98-104 (August 2001) DOI: 10.1016/S1525-1578(10)60658-7 Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 Structure of the Class I and II heterodimers. The Journal of Molecular Diagnostics 2001 3, 98-104DOI: (10.1016/S1525-1578(10)60658-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 DRB1 Gene polymorphism. Single letter amino acid codes are shown for DRB1 exon 2 codons 6–94. About half of the positions are invariant while the remainder display polymorphism with a few codons encoding as many as seven different amino acids. For example, all DRB1 alleles have glycine encoded by position 20 while alleles may encode glycine, valine, or aspartic acid at codon 86. The 289 known DRB1 alleles arise through the many possible combinations of these polymorphisms. The polypeptide encoded by DRB1*0101 is shown on the top line. The Journal of Molecular Diagnostics 2001 3, 98-104DOI: (10.1016/S1525-1578(10)60658-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 3 Class I and Class II alleles arise from existing alleles through several postulated mechanisms.15 DRB1*1120 likely arose via interallelic recombination between DRB1*1302 and a DRB1*11 allele,35 while DRB1*0811 probably is derived from DRB1*0802 by a point mutation.14 The Journal of Molecular Diagnostics 2001 3, 98-104DOI: (10.1016/S1525-1578(10)60658-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions