Twenty-year follow-up of a familial case of PTH1R-associated primary failure of tooth eruption Cláudia Misue Kanno, José Américo de Oliveira, José Fernando.

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Twenty-year follow-up of a familial case of PTH1R-associated primary failure of tooth eruption Cláudia Misue Kanno, José Américo de Oliveira, José Fernando Garcia, Helmut Roth, Bernhard H.F. Weber American Journal of Orthodontics and Dentofacial Orthopedics Volume 151, Issue 3, Pages 598-606 (March 2017) DOI: 10.1016/j.ajodo.2016.09.012 Copyright © 2016 American Association of Orthodontists Terms and Conditions

Fig 1 A, Panoramic radiograph of patient II.9 at age 15 years, showing a unilateral open bite with involvement of the deciduous molars, with no mechanical interference. At the ages of B, 23 and C, 42, progressive intrusive movement of the maxillary left canine and mandibular right third molar can be observed. D, Clinical aspect at age 42, with the maxillary left canine in infraocclusion. American Journal of Orthodontics and Dentofacial Orthopedics 2017 151, 598-606DOI: (10.1016/j.ajodo.2016.09.012) Copyright © 2016 American Association of Orthodontists Terms and Conditions

Fig 2 Panoramic radiographs of various members of the family during the follow-up period, showing the phenotypic variability: A, patient I.2 (male) at age 62; B, patient II.3 (male) at age 32; C, patient II.5 (male) at age 47; D, patient II.8 (female) at age 21; E, patient II.11 (male) at age 37; F, patient II.12 (male) at age 20. American Journal of Orthodontics and Dentofacial Orthopedics 2017 151, 598-606DOI: (10.1016/j.ajodo.2016.09.012) Copyright © 2016 American Association of Orthodontists Terms and Conditions

Fig 3 Heredogram showing an autosomic dominant pattern of inheritance. American Journal of Orthodontics and Dentofacial Orthopedics 2017 151, 598-606DOI: (10.1016/j.ajodo.2016.09.012) Copyright © 2016 American Association of Orthodontists Terms and Conditions

Fig 4 A and B, Plastic models of patient II.11 when he was 18 years old, showing bilateral open bite at the area of the first molars; C and D, clinical images taken after 20 years show that the maxillary left first molar and the mandibular right first molar reached the occlusal level. American Journal of Orthodontics and Dentofacial Orthopedics 2017 151, 598-606DOI: (10.1016/j.ajodo.2016.09.012) Copyright © 2016 American Association of Orthodontists Terms and Conditions

Fig 5 A and B, Tomographic images of patient II.12 at age 40, showing multiple cervical resorptions in posterior maxillary teeth (arrows); note the subgingival position of root resorptions. Details of the panoramic radiographs of C, patient I.2 and D, patient II.11, showing radiolucencies with scalloped margins at the cementoenamel junction. American Journal of Orthodontics and Dentofacial Orthopedics 2017 151, 598-606DOI: (10.1016/j.ajodo.2016.09.012) Copyright © 2016 American Association of Orthodontists Terms and Conditions

Fig 6 Patient II.13: A, at age 13 and B, at age 32. The condition became more severe in adulthood with the involvement of anterior teeth of the right side. American Journal of Orthodontics and Dentofacial Orthopedics 2017 151, 598-606DOI: (10.1016/j.ajodo.2016.09.012) Copyright © 2016 American Association of Orthodontists Terms and Conditions