F32 Individual Fellowships, Early Independence Award NIH Grants: F32 Individual Fellowships, F99 / K00 Early Independence Award January 27, 2017

http://bsdpostdoc.uchicago.edu/page/funding

NIH Research Funding Support by Career Stage Postdoc https://www.niaid.nih.gov/researchfunding/traincareer/pages/careerphd.aspx 3

NIH Nomenclature FOA means Funding Opportunity Announcement. FOA is the generic “umbrella” term for all types of funding mechanisms offered by the NIH. RFA means Request for Applications. The F99/K00 is an RFA. This means it has special terms – like having a Letter of Intent and only having one annual submission date. NRSA refers to National Research Service Awards – these are the congressionally-mandated fellowships offered by NIH – the F30 is for MD/PhDs, F31 is for graduate students, and F32 is for postdocs. https://www.cancer.gov/grants-training/training/funding/f99

F32: Competing applications, awards, and success rates Data and chart description for this slide can be located at http://report.nih.gov/NIHDatabook/Charts/Default.aspx?showm=Y&chartId=106&catId=13 FY 2015: 25% Success Rate http://report.nih.gov/NIHDatabook/Charts/Default.aspx?showm=Y&chartId=106&catId=13 5

NINDS F32: Ruth L. Kirschstein Postdoctoral Individual National Research Service Award The purpose of this award is to support outstanding scientific training of highly promising postdoctoral candidates with outstanding mentors…Based on the early timeframe of eligibility, and the discouragement of inclusion of preliminary data, this NINDS F32 seeks to foster early, goal-directed planning and to encourage applications for bold and/or innovative projects by the candidate that have the potential for significant impact… Due Dates: April 8, August 8, December 8 Eligibility: Permanent Resident or Citizen of the US; 12 month before starting postdoc or within 12 months of starting Only applies to NINDS Duration: Limited to 3 years. Awardees incur 2 years of payback. Repay year 1 by staying in research a 2nd year. https://researchtraining.nih.gov/programs/fellowships/F32 https://grants.nih.gov/grants/guide/pa-files/PAR-16-458.html

F32: Ruth L. Kirschstein Postdoctoral Individual National Research Service Award The purpose of the Kirschstein-NRSA postdoctoral fellowship is to enhance the research training of promising postdoctoral candidates who have the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of the participating NIH Institutes and Centers. Due Dates: April 8, August 8, December 8 Eligibility: Permanent Resident or Citizen of the US Participating NIH institutes and centers: NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINR, NIMHD, NCCIH (Check http://grants.nih.gov/grants/guide/contacts/parent_F32.html for details on institute participation and mission.) Duration: typically for 3 years. Awardees incur 2 years of payback. Repay year 1 by staying in research a 2nd year. https://researchtraining.nih.gov/programs/fellowships/F32 http://grants.nih.gov/grants/guide/pa-files/PA-14-149.html

NIH Research Funding Support by Career Stage Postdoc F99 / K00 is a pilot program 8

NINDS F99/K00 - NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award The purpose of the D-SPAN Award is to support a defined pathway across career stages for outstanding graduate students who are from diverse backgrounds underrepresented in neuroscience research….For the F99/K00 award, individuals may receive up to 6 years combined support for both phases, which includes up to 2 years in the F99 fellowship phase and up to 4 years in the K00 career development phase. Due Dates: April 8, (Letter of Intent due 1 month before) Eligibility: Permanent Resident or Citizen of the US; 12-24 months before starting postdoc Participating NIH institutes and centers: NINDS, NEI, NIA, NIAAA, NIBIB, NICHD, NIDCR, NIDA, NIEHS, NIMH, NINR, NCCIH, OBSSR Duration: may receive up to 6 years combined support for both phases, which includes up to 2 years in the F99 fellowship phase and up to 4 years in the K00 career development phase. https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-009.html

NCI F99/K00 - Predoctoral to Postdoctoral Fellow Transition Award The purpose is to encourage and retain outstanding graduate students who have demonstrated potential and interest in pursuing careers as independent cancer researchers. The award will facilitate the transition of talented graduate students into successful cancer research postdoctoral appointments, and provide opportunities for career development activities relevant to their long-term career goals of becoming independent cancer researchers. Due Dates: Feb 17, 2017 (Deadline passed, Letter of Intent due one month before) Eligibility: No Citizenship Requirement; 3rd / 4th year PhD students (within 24 months of defending), On nomination per institution (internal university nomination process) Participating NIH institutes and centers: NCI Only Duration: may receive up to 6 years combined support for both phases, which includes up to 2 years in the F99 fellowship phase and up to 4 years in the K00 career development phase. Has a separate application and review process, webinar slides available at: https://www.cancer.gov/grants-training/training/funding/f99 https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-17-014.html

NIH Director’s Early Independence Award Program The program supports exceptional investigators who wish to pursue independent research directly after completion of their terminal doctoral/research degree or clinical residency, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career.  Due Dates: Most likely Sept 2017 (Letter of Intent due 1 month before) Eligibility: No Citizenship Requirement; 12 months before or after terminal degree; Two applicants per institution (internal university nomination process) Duration: 5 years Requirements: 3-5 letters of reference, institutional support Two phases of review https://commonfund.nih.gov/earlyindependence/index

Successful Application F32 Application Ingredients Successful Application Science Mentor & Training Plan Trainee

More than Research  incorporate Training Goals Main Application Components Referees: 3 letters of reference are submitted by the writer on eRA Commons Letters of Support: from collaborators, co-mentors Mentor Statement Biosketch: yours and mentors. Includes grades and courses. Specific Aims - 1 page Research Strategy – 6 pages Responsible Conduct of Research – 1 page Goals – 1 page Activities planned – 1 page More than Research  incorporate Training Goals

Review Process Center for Scientific Review (CSR) – Rosters are posted online with meeting dates http://public.csr.nih.gov/StudySections/Fellowship/Pages/default.aspx 3 reviewers assigned from a study section (not familiar with details of your work, busy, overworked) Scientific Review Administrator Scores 1-9 are averaged to give an impact score Study section meets: best scored grants discussed first, final scores after discussion are given as a percentile Summary Statement of scores Institute Review Funding decision

Review Criteria Main Review Criteria 1. Overall Impact Assessment of the likelihood that the proposed training will enhance the candidate’s potential for a productive, independent scientific career. 2. Five Core Review Criteria Applicant Mentor(s), sponsors, collaborators Research Training Plan Training Potential Institutional Environment and Commitment to Training Additional Criteria – Training in the Responsible Conduct of Research

Five Core Review Criteria Fellowship Applicant Scholastic performance Productivity commensurate with career stage Aptitude and enthusiasm Clarity of stated career goals Letters of reference Mentoring committee for pre-docs is a plus 2. Sponsors, Collaborators, and Consultants Documented mentoring successes Expertise in the field Present productivity Funds available to cover research expenses Co-mentor to cover weaknesses Clearly defined roles for mentors and collaborators 3. Research Training Plan Significance & impact of the proposed research Logical hypothesis Clarity, feasibility and alternative strategies Stats, vertebrate animals, human subjects Sophisticated technologies and approaches Likelihood training will lead to publications and degree Appropriate for the applicant fellow’s stage of research development 4. Training Potential Is there individualized training that addresses weaknesses and career development needs? Will participants learn new technical skills, new design approaches? Do training activities match career goals? Will training confer an advantage to competitive? Will the applicant fellow receive requisite individualized and supervised experiences? 5. Institutional Environment and Commitment to Training Scientific environment Opportunities for collaborations within and outside institution if needed Resources available https://grants.nih.gov/grants/peer/critiques/f_D.htm

What Reviewers Look for in Fellowship Applications Impact Exciting ideas Clarity of the research and training plans Realistic aims and timelines– Don’t be overly ambitious Brevity with things that everybody knows Noted limitations of the study A clean, well-written application

Training in the Responsible Conduct of Research Reviewers are asked to state whether the proposed training is “Acceptable” or “Not Acceptable” Is there formal and face-to-face training? Are all ethical topics clearly depicted? Are faculty participating in the training? Will the total hours of training be at least 8 contact hours? Are future opportunities/refreshers for continued training listed? Does retraining occur every 4 years or at every career stage?

NIH Grant Writing Resources NIAID Grant Resources https://www.niaid.nih.gov/researchfunding/traincareer/pages/default.aspx Postdoc’s Guide to Gaining Independence https://www.niaid.nih.gov/grants-contracts/postdoc-guide NIMH Grant Application Process http://www.nimh.nih.gov/funding/grant-writing-and-application-process/index.shtml

Policies NIH: Stipend – follows NIH NRSA Levels FY 2017: $47,484 minimum Institutional Allowance - $7,850 includes health insurance Travel Allowance - $1,000 per year Payback https://grants.nih.gov/grants/policy/nihgps/HTML5/section_11/11.4_payback_requirements.htm BSD: Stipend supplement of $1,800 Switch from Postdoctoral Scholar to Fellow http://bsdpostdoc.uchicago.edu/page/benefits-health-insurance

Updates from the NIH Biosketch format - NOT-OD-16-080 Restructured application instructions - NOT-OD-16-084 How to Apply Application Guide - http://grants.nih.gov/grants/how-to-apply-application-guide.htm#format# NRSA Stipend Levels for FY17 https://grants.nih.gov/grants/guide/notice-files/NOT-OD-17-003.html