Pharmacology Tutoring for Drugs of Abuse By Alaina Darby adarby1@uthsc.edu

Which of the following defines addiction? Tolerance to the substance Withdrawal syndrome Compulsive drug use Withdrawal symptoms relieved with readministration C

Which of the following functions as the “brake” for other pathways in the brain and becomes weakened with continued exposure to drugs? VTA Frontal cortex Striatum Nucleus accumbens B

Which of the following is involved in motivated behavior? VTA Frontal cortex Striatum Nucleus accumbens D

Which of the following people are more likely to experience addiction? Prior experience with drugs Slower drug metabolism Underdeveloped frontal cortex Innate tolerance B

Which of the following is an environmental factor that could discourage addiction? Drug paraphanalia Peer pressure Employment Psychiatric symptoms C

Behavioral learned tolerance Conditioned learned tolerance Which of the following categories would you classify the following scenario into: someone who learns to walk a straight line while drunk? Behavioral learned tolerance Conditioned learned tolerance Innate tolerance Acute tolerance A

Tetrahydrocannabinol Cannabigerol Which of the following is the primary psychoactive ingredient in marijuana? Cannabidiol Cannabinol Tetrahydrocannabinol Cannabigerol C

Which of the following is associated with early stages of a marijuana high? Relaxation Introspective Depersonalization Difficulty thinking C

Decreased concentration Apathy Increased hunger Decreased judgement Which of the following is most indicative of acute marijuana use as opposed to chronic use? Decreased concentration Apathy Increased hunger Decreased judgement C

Which of the following is a hallmark sign of THC use? Increased heart rate Immunosuppression CNS depression Endocrine effects A

Follicle-stimulating hormone Growth hormone Which of the following is a hormone that is not decreased by marijuana use? Luteinizing hormone Follicle-stimulating hormone Growth hormone Adrenocorticotropin hormone D

For which of the following conditions would smoking marijuana help with initially but not if used chronically? Asthma Diabetes Heart disease Obesity A

Which of the following is not a function of 2- aracidonylglycerol? Neuroprotection Suppress aversive memories Depress food intake Inhibit muscle contraction C

In which of the following brain regions are cannabinoid receptors least concentrated? Central gray Hippocampus Cerebellum Basal ganglia A

Which of the following is the most potent and active? Δ9-THC 11-Hydroxy-Δ9-THC 8-Hydroxy-Δ9-THC 11-nor-Δ9-THC-9-carboxylic acid B

Which of the following is the main metabolite that is excreted? Δ9-THC 11-Hydroxy-Δ9-THC 8-Hydroxy-Δ9-THC 11-nor-Δ9-THC-9-carboxylic acid D

Which of the following is not true of marijuana tolerance? Caused by inhibition of adenylyl cyclase Caused by decreased receptors Cross tolerance with alcohol Cross tolerance with opioids A

Which of the following is not a hazard of marijuana use? Development of schizophrenia Development of squamous cell hyperplasia Low birth weight and head circumference in offspring Development of insomnia D

For which of the following is medical marijuana approved? Multiple sclerosis Tourette’s syndrome AIDS wasting syndrome L-dopa-induced dyskinesias C

Which of the following would be a use for CB1 selective antagonists? Immune suppression Neuroinflammation Chronic pain Obesity D

Which of the following inhalants are used primarily as sexual enhancers? Volatile solvents Nitrites Gases Aerosols B

Which of the following results from heavy use of inhalants? Euphoria Dizziness Drowsiness Delusions C

Which of the following is not an effect of inhalant use on the brain? Demyelination Slowed conduction Spasticity Increased sensory input D

Which of the following is the typical cause of death from inhalants? Liver failure Kidney failure Cardiac arrhythmia Stroke C

Which of the following categories of drugs has a stimulatory effect on the brain and may be used in those with mental disorders to encourage introspection? Inhalants Hallucinogens Cannabinoids Opioids B

What is the mechanism of action for LSD? Partial 5-HT2 receptor agonist Full 5-HT2 receptor agonist Partial dopamine receptor agonist Full dopamine receptor agonist A

Tricyclic antidepressants Opiates Antipsychotics Which of the following can be used to treat acute adverse effects from LSD? Benzodiazapines Tricyclic antidepressants Opiates Antipsychotics A

Which of the following interacts with a receptor that usually causes dysphoria? Psilocybin Mescaline Salvia divinorum Phencyclidine C

Which of the following is a dopamine and norepinephrine reuptake inhibitor and also antagonizes the NMDA receptor? Psilocybin Mescaline Salvia divinorum Phencyclidine D

Which of the following hallucinogens can be overdosed? Psilocybin Mescaline Salvia divinorum Phencyclidine D

Which of the following is an action for MDMA? Increased neurotransmitter release NMDA receptor antagonism Serotonin receptor agonist Opioid receptor agonist A

Which of the following is an action for LSD? Increased neurotransmitter release NMDA receptor antagonism Serotonin receptor agonist Opioid receptor agonist C

Which of the following is an action for mescaline? Increased neurotransmitter release NMDA receptor antagonism Serotonin receptor agonist Opioid receptor agonist C

Which of the following is an action for PCP? Increased neurotransmitter release NMDA receptor antagonism Serotonin receptor agonist Opioid receptor agonist B

Which of the following is an action for salvia divinorum? Increased neurotransmitter release NMDA receptor antagonism Serotonin receptor agonist Opioid receptor agonist D

Increases the number of serotonin transporters Which of the following describes the studied effect of MDMA on serotonin in the brain? Increases the number of serotonin transporters Decreases the number of serotonin transporters Increases the number of serotonin receptors Decreases the number of serotonin receptors B

Dissociative anesthesia Memory loss Disorientation Which of the following is associated specifically with the abuse of cough syrup in large doses? Delirium Dissociative anesthesia Memory loss Disorientation B