Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow by Cesare Campagnoli, Irene A. G. Roberts,

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Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow by Cesare Campagnoli, Irene A. G. Roberts, Sailesh Kumar, Phillip R. Bennett, Ilaria Bellantuono, and Nicholas M. Fisk Blood Volume 98(8): October 15, 2001 ©2001 by American Society of Hematology

MSCs isolated and cultured in the first trimester.A-D, fetal blood (9+2 weeks); E-H, fetal liver (10+2 weeks); and I-L, fetal bone marrow (11+2weeks. Cesare Campagnoli et al. Blood 2001;98: ©2001 by American Society of Hematology

Growth curves of first-trimester MSCs from fetal blood, fetal liver, and fetal bone marrow.Fetal MSCs were plated at a density of cells/cm2, duplicate cultures were harvested each day for 16 days, and the number of adherent cells was determined. Cesare Campagnoli et al. Blood 2001;98: ©2001 by American Society of Hematology

Immunophenotype of fetal MSCs by FACS analysis.MSCs (at the second and tenth passages in culture) from fetal blood (A; n = 6), liver (B; n = 4), and bone marrow (C; n = 4) were stained with surface antibodies and analyzed by FACS. Cesare Campagnoli et al. Blood 2001;98: ©2001 by American Society of Hematology

Coculture of fetal MSCs with umbilical cord blood CD34+ hematopoietic stem–progenitor cells.Umbilical cord blood CD34+ cells were cocultured with fetal blood MSCs for 6 weeks (n = 2) and for 8 weeks (n = 1) (●). Cesare Campagnoli et al. Blood 2001;98: ©2001 by American Society of Hematology

Differentiation of fetal MSCs from into adipocytes, osteocytes, and chondrocytes.First-trimester fetal blood (9+2 weeks; A-C), fetal liver (14+0 weeks; D-F), and fetal bone marrow (11+2weeks; G- I) into adipocytes, osteocytes, and chondrocytes. Cesare Campagnoli et al. Blood 2001;98: ©2001 by American Society of Hematology