Bacteriophages They are viruses that infect bacteria i.e. bacterial viruses (bacteria eater).

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Presentation transcript:

Bacteriophages They are viruses that infect bacteria i.e. bacterial viruses (bacteria eater).

Main items 3-Replication 1-Discovery 2-General characteristics 4-Importance

Main items 1-Discovery

Discovery Twort (1915) D“herelle (1917)

Lytic agent may be a virus Bacteria + solid agar Thermal treatment

Bacillus dysentrae + solid agar Phenomenon due to bacteriophage

Main items 1-Discovery 2-General characteristics

General characteristics 1.Widely distributed. 2.Structure. 3.Symmetry. 4.Nucleic acid. 5.Morphology. 6.Replication. 7.Size 8.Cultivation.

General characteristics 1.Widely distributed. 2.Structure. 3.Symmetry. 4.Nucleic acid. 5.Morphology. 6.Replication. 7.Size 8.Cultivation.

General characteristics 1.Widely distributed. 2.Structure. 3.Symmetry. 4.Nucleic acid. 5.Morphology. 6.Replication. 7.Size. 8.Cultivation.

: Symmetry : 1. Helical 2. Cubic

General characteristics 1.Widely distributed. 2.Structure. 3.Symmetry. 4.Nucleic acid. 5.Morphology. 6.Replication. 7.Size. 8.Cultivation.

General characteristics 1.Widely distributed. 2.Structure. 3.Symmetry. 4.Nucleic acid. 5.Morphology. 6.Replication. 7.Size. 8.Cultivation.

A B C D E F

General characteristics 1.Widely distributed. 2.Structure. 3.Symmetry. 4.Nucleic acid. 5.Morphology. 6.Replication. 7.Size. 8.Cultivation.

Replication 1. Virulent (Lytic) 2. Avirulent (lysogenic or temperate)

General characteristics 1.Widely distributed. 2.Structure. 3.Symmetry. 4.Nucleic acid. 5.Morphology. 6.Replication. 7.Size. 8.Cultivation.

Main items 3-Replication 1-Discovery 2-General characteristics

Lytic cycle Replication Penetration Adsorption Assembly Releasing

Summary of virulent cycle

Lysogeny cycle Integration Penetration Adsorption Bacterial duplication Spontaneous induction Replication Assembly Releasing

Mutation of temperate phage to virulent phage Resistant to repressor molecule. Loss repressor molecule production.

Main items 3-Replication 1-Discovery 2-General characteristics 4-Importance

Importance Viral research Genetic engineering Viral pathogenicity Medical diagnosis (phage typing by virulent) Medical aspects of lysogeny (lysogenic conversion)