Essential Questions  What are the functions of the urinary system?  What are some disorders of the urinary system?  How are disorders of the urinary system treated?  How do you relate the body’s hormone control to the urinary system? 4.02 Understand the functions and disorders of the urinary system 2

Functions :  Excretion  Formation of urine  Fluid and electrolyte balance  Elimination of urine 4.02 Understand the functions and disorders of the urinary system 3

Functions :  Excretion  Formation of urine  Fluid and electrolyte balance  Elimination of urine 4.02 Understand the functions and disorders of the urinary system 4

Excretion  What is excretion? Getting rid of wastes  Why does the body have excretory functions? rid the body of toxins  What is the composition of wastes excreted by the urinary system? Urea, Na, K, creatinine, water  How is it relevant to health? 4.02 Understand the functions and disorders of the urinary system 5

Filtration Reabsorption Secretion 6

Blood from renal artery enters glomerulus High pressure in glomerulus forces fluid into Bowman’s capsule, where it is filtered 7

BOWMAN’S CAPSULE  Bowman’s capsule filters out 125cc of fluid/min. …how many cc’s per hour is this?  As the filtrate continues through nephron, 90% of water is reabsorbed—what would happen if reabsorption here failed? 4.02 Understand the functions and disorders of the urinary system 8

 What substances are reabsorbed?  Where do they go? Back into the bloodstream  If blood levels of certain substances are high, the substances will not be reabsorbed.  How does this help maintain homeostasis? 4.02 Understand the functions and disorders of the urinary system 9

What is secretion? glandular Describe how this process is the opposite of reabsorption…detected by negative feedback loop 10

 What substances are secreted into the collecting tubules? Certain Electrolytes (hydrogen ions) secreted into the tubule for excretion  Where reasbsorption occurs: distal convoluted tubule 4.02 Understand the functions and disorders of the urinary system 11

Fluid and electrolyte balance  Electrolytes are selectively secreted to maintain body’s acid-base balance. What are electrolytes?  Minerals in blood that carry An electrical charge What do they do?  Help maintain homeostasis 4.02 Understand the functions and disorders of the urinary system 12

Fluid and electrolyte balance Chemical control ADH- antidiuretic hormone Aldosterone- Regulates salt and water balance Nervous control- pituitary gland secretions help control blood pressure and water, and salt balances 4.02 Understand the functions and disorders of the urinary system 13

Fluid and electrolyte balance Chemical control  ADH  ADH is released by the posterior pituitary gland  What is the function of ADH (antidiuretic hormone)? 4.02 Understand the functions and disorders of the urinary system 14

Fluid and electrolyte balance Chemical control ADH  The amount of ADH produced is related to the level of body hydration ADH  What factors regulate the release of ADH? 4.02 Understand the functions and disorders of the urinary system 15

Forming more dilute urine: Define “dilute urine”  What are diuretics?  What effect do they have on the production of urine?  Give examples of substances that have diuretic effects Understand the functions and disorders of the urinary system 16

Fluid and electrolyte balance Chemical control Aldosterone  Where does it come from? Adrenal gland  What does it do? Conserves N, K  Aldosterone release is the result of the renin- angiotensin system. What does this mean? Renin is released when there is decreased blood flow to the kidneys. This causes a plasma protein to be converted to angiotensin which causes aldosterone to be release which increases blood pressure Understand the functions and disorders of the urinary system 17

Fluid and electrolyte balance 4.02 Understand the functions and disorders of the urinary system What effect does this cycle have on your blood pressure? 18

Fluid and electrolyte balance Nervous control  How does the nervous system control urinary secretions?  What other systems are involved in the production and excretion of urine? 4.02 Understand the functions and disorders of the urinary system 19

4.02 Understand the functions and disorders of the urinary system Review urine formation, electrolyte exchange, and some factors that effect urine volume. 20

 What do you predict will happen to blood pressure when the blood volume increases?  What if blood volume decreases? 4.02 Understand the functions and disorders of the urinary system review 21

 If more water is reabsorbed back into the body---what will happen to urine concentration?  (more or less concentrated?)  If more water is reabsorbed back into the body---what will happen to urine concentration?  (more or less concentrated?) 4.02 Understand the functions and disorders of the urinary system review 22

Elimination of urine What causes the bladder to empty? Is this a voluntary or involuntary action? What can prevent urination? How is urinary retention treated? 4.02 Understand the functions and disorders of the urinary system 23

Elimination of urine Urinary output 4.02 Understand the functions and disorders of the urinary system Average urinary output = 1500 ml per day * How many ounces is this? What effects the color of your urine? 24

An examination of urine  What does normal urine look like? Amber (light yellow)  What constitutes an abnormal urinalysis? Blood, pus, protein, glucose 4.02 Understand the functions and disorders of the urinary system 25

4.02 Understand the functions and disorders of the urinary system What could the presence of blood in urine indicate? What is the medical term for this condition? 26

4.02 Understand the functions and disorders of the urinary system 27

4.02 Understand the functions and disorders of the urinary system 28

4.02 Understand the functions and disorders of the urinary system 29

Cystitis  What is cystitis (cyst= medical term for ____ +itis =___ )  Most common cause: E. Coli  What are the major symptoms of cystitis? Dysuia Frequency with little output 4.02 Understand the functions and disorders of the urinary system 30

Cystitis  More common in females—Why ?? 4.02 Understand the functions and disorders of the urinary system Rx= antibiotics 31

Glomerulonephritis 4.02 Understand the functions and disorders of the urinary system  Disease which injures the glomerulus.  What will happen as a result of damaged glomeruli? Substances normally reabsorped will be spilled into urine. Eventually filtering will cease. 32

Glomerulonephritis  Two types: Acute- suddenly Chronic- (over time may be silent)  How do these terms relate to glomerulonephritis symptoms? Blood in urine, puffiness.  What is the prognosis for each? Both may required dialysis, acute may resolve on its own, BP meds, transplant 4.02 Understand the functions and disorders of the urinary system 33

Renal calculi Also known as nephrolithiasis nephro lith iasis nephro lith iasis What are renal calculi made of? calcium What are the symptoms? unrelenting pain, fever, hematuria 4.02 Understand the functions and disorders of the urinary system 34

Renal calculi  What will happen if the ureters are blocked? hydronephrosis 4.02 Understand the functions and disorders of the urinary system 35

Renal calculi  How is it treated? IV fluids lithotrpsy 4.02 Understand the functions and disorders of the urinary system 36

Renal calculi  How does lithotripsy work?  Is it a cure? 4.02 Understand the functions and disorders of the urinary system 37

Renal failure  Acute What causes it? Excessive blood loss, sepsis, blockage (stones), cancer, come medications What causes it? Excessive blood loss, sepsis, blockage (stones), cancer, come medications What are the symptoms? Oliguria (first symptom), swelling, N &V, confusion What are the symptoms? Oliguria (first symptom), swelling, N &V, confusion 4.02 Understand the functions and disorders of the urinary system 38

Renal failure chronic  May be none in early stages, urinalysis may reveal proteinuria  Why would protein be present in the urine? Glomerulus damage  Why is this not normal? Normally reapsorbed 4.02 Understand the functions and disorders of the urinary system 39

Renal Failure  Chronic kidney disease leads to a buildup of fluid and waste products in the body.  How are these systems affected by renal failure? Poor appetite Bruising, swelling SOB 4.02 Understand the functions and disorders of the urinary system 40

Renal Failure  How is it treated? Peritoneal dialysis Peritoneal dialysis What is the process involved in this treatment? 4.02 Understand the functions and disorders of the urinary system 41

Renal Failure  How is it treated? Hemodialysis Hemodialysis What is hemodialysis? What is hemodialysis? What determines the patient’s treatment schedule? Severity of the damage What determines the patient’s treatment schedule? Severity of the damage 4.02 Understand the functions and disorders of the urinary system 42

Renal Failure  Compare the treatment of acute and chronic renal failure Understand the functions and disorders of the urinary system 43

How does hemodialysis mimic glomerular function? 4.02 Understand the functions and disorders of the urinary system 44

Renal transplant  What is involved in this treatment option?  When does a patient get a transplant? 4.02 Understand the functions and disorders of the urinary system 45

Renal transplant 4.02 Understand the functions and disorders of the urinary system What is the major complication of renal transplantation? Rejection 46

 Essential Questions  What are the functions of the urinary system?  What are some disorders of the urinary system?  How are disorders of the urinary system treated?  How do you relate the body’s hormone control to the urinary system? 4.02 Understand the functions and disorders of the urinary system 47