Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Insulin Therapy for Type 2 Diabetes Mellitus JAMA. 2014;311(22): doi: /jama Initial Publication Search, a Trials were examined for safety outcomes if they were large randomized clinical trials in diabetes mellitus and had adult patient populations, blind assessment, and prespecified outcomes and reported results from January 1998 to April b The appendixes of all 7 randomized trials were reviewed. Figure Legend:

Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Insulin Therapy for Type 2 Diabetes Mellitus JAMA. 2014;311(22): doi: /jama Subsequent Publication Searches, FDA indicates US Food and Drug Administration. Figure Legend:

Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Insulin Therapy for Type 2 Diabetes Mellitus JAMA. 2014;311(22): doi: /jama Suggested Algorithm for Initiating Insulin in Patients With Type 2 DiabetesThis suggested approach has not been validated in randomized trials. HbA 1c indicates hemoglobin A 1c ; GLP-1, glucagon-like peptide 1; SGLT-2, sodium glucose cotransporter 2; and DPP-4, dipeptidyl peptidase 4. Figure Legend: