Case of Week 감염면역 내과 Prof. 이미숙 / R2 이윤정
Chief complaint Rt. Facial pain onset) 내원 10 일전 Present illness 특별한 medical Hx. 와 약물 복용력 없는 63 세 여자 환자로 내원 10 일전부터 생긴 지속적인 Rt. Facial pain 으로 건국대 병원에서 검사 상 특이소견 보이지 않았으나, 증상 지속되어 본원 응급실 경유하여 신경과로 입원함. ( 건국대 병원 Brain MRI : Sphenoid sinusitis 외에 특이 소견없음 ) Patient’s history 김 0 자 (F/63) Adm
Medical history DM/HTN/TB/Hepatitis ( -/ -/ - /- ) OP Hx. (- ), 여행력 (-) Family history Unremarkable Personal history Alcohol (-), Smoking(-) Occupation : 주부 Patient’s history
General : fatigue(-) fever(-) chills(-) sweat(-) weight loss(-) Head & Neck : headache(-) trauma(-) Ext. wound (-) stiiffness(-) Rt. Facial pain (+): trigerminal area( V2, V3 ara), lancinating pain, continuous, Rt.facial edema (-) heatness(-) Eye & ENT : sore throat(-) gingival swelling(-) rinorrhea (-) post nasal drip (-) visual disturbance(-),diplopia (-) Respiratory : cough(-) sputum(-) hemoptysis(-) Cardiac : chest pain(-) dyspnea(-) palpitation(-) Gastrointestinal : A/N/V/D/C(-/-/-/-/-) abdomial pain (-) Neurology : dizziness(-) tremor(-) syncope (-) Review of System
Physical Examination V/S : 110/60 mmHg-84 회 /min-20 회 /min-36.3°C General apperance Mental : alert Acutely ill appearance Skin no rash or pigmentation Head & Neck no thyroid gland enlargement no neck vein engoregement no thyroid gland enlargement Rt. Facial tenderness (-) Rt. Facial tenderness (-) Eye & ENT isocoric pupil with PLR(++/++), EOM : full without nystagmus pinkish conjunctiva not icteric sclera Physical Examination
Thorax symmetric chest expansion clear breathing sound without rale regular heart beat without murmur Abdomen soft and flat abdomen normoactive bowel sound no hepatosplenomegaly Back / Extremity pretibial pitting edema(-/-) Neurologic examination babinsky (-/-), unremarkable finding Physical Examination
Chest x-ray
CBC/DC 5990/mm g/dL % /mm 3 (seg.:65.4%) INR :1.08 % a-PTT : 42 C 33 sec Chemistry TB/DB 0.8 / 0.3 mg/dL AST/ALT 18 / 10 IU/L ALP / rGT 97 / 12 IU/L Prot/Alb 6.9 / 3.2 g/dL Glucose 105 mg/dL BUN/Cr 8 / 0.5 mg/dL Na/K/Cl 137 / 3.9 / 101 mmol/L Ca/P/ Mg 9.4 / 3.7 / 3.2 mg/dL ( / / ) CRP 3.4 mg/dl ( < 0.5 ) U/A RBC 0-1 /HPF, WBC 2-4 /HPF Initial Lab Finding ( )
Trigerminal neuralgia Pain control, Steroid Tx. 고려 Pain 호전 되지 않을 경우 OP (microvascular decompression) 고려 Impression & Plan
Trigerminal neuralgia Gabapetin 300mg,tid.po Carbamazepine 50mg,bid,p.o Tramadol 50mg,tid.p.o Prednisolone p.o 30mg ( 아침 ), 10mg( 저녁 ) 시작하여 점차 감량함 H/D D4 ~ D26 ( ~9.20) Pain 은 호전되지 않고 drug side effect 로 nausea,vomitimg, poor oral intake 보임, intractable trigerminal neuralgia 로 op 고려하기로 함
Rt. Periorbital, perinasal, frontal area 에 새롭게 dull pain 발생함, nasal obstruction (+), fever (-) PNS CT 시행함 H/D D27~D31 ( ~9.25)
PNS CT (09.20)
ENT 에서 Express Bx. 시행함 (fungal infection ) Amphotericin B 시작함 endoscopic exploration and removal of fungal material Bx :Anterior and posterior, ethmoid sinus, excision: Acute and chronic inflammation with aspergillosis Paranasal sinus, posterior, ethmoid sinus, excision: Aspergilloma Paranasal sinus, sphenoid sinus, excision: Aspergilloma 감염내과로 전과됨 H/D D27~D31 ( ~9.25)
부터 Rt. Eye 의 시력저하, diplopia (+) nystagmus (-), ptosis Rt. (+) : 눈이 위로 잘 안떠지는 증상 보임 PNS CT : Bulging contour of right cavernous sinus Brain MRI : Invasion of optic foramen and orbital apex 안과 consult 에서 cranial nerve II,III,VI injury 로 Rt.eye EOM 의 장애 Rt.eye 적출술 필요하나 환자, 보호자 refuse 함 H/D D36~D48 ( ~10.12)
PNS CT (10.07)
BRIAN MRI (10.12) & PNS CT (11.20)
차 endoscopic exploration and removal of fungal material 시행 Pain 감소, F/U PNS CT 시행 Rt.facial pain 감소, anorexia,nausea,poor oral intake 호전되어 ictraconazole 200mg,bid,po 로 퇴원함 H/D D78~ 퇴원 ( ~12.13)
증상 악화 PO change Total dose : 3.5g LFT F/U Liposomal amphotericin B 5mg/kg,qd,iv Caspofungin 50mg, qd, iv Ictraconazole 200mg,bid,p.o Amphotericin B 09.22~ ~10.17 Nausea,vomiting anorexia ~ ~12.13 Anti-fugal agent 치료경과
OPD F/U 시에는 Ictraconazole 200mg,bid.p.o 로 계속 유지 하고 있음 OPD F/U 시에는 AST/ALT 85/36 로 상승 소견 보여 ictraconazole stop 함 OPD F/U
Rhino-orbito-cerebral aspergillosis Final diagnosis