Transcriptional targets shared by estrogen receptor ‐ related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ by Jean ‐ Marc Vanacker, Katarina.

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Transcriptional targets shared by estrogen receptor ‐ related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ by Jean ‐ Marc Vanacker, Katarina Pettersson, Jan ‐ Åke Gustafsson, and Vincent Laudet EMBO J. Volume 18(15): August 2, 1999 ©1999 by European Molecular Biology Organization

Binding of ERs and ERRs to common DNA targets. Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization

Specificity of binding of ERα, ERRα and ERRβ to ERE and SFRE probes. Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization

ERα and ERRα bind as homodimers. Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization

Transcriptional activities of ERs and ERRs. Rat osteosarcoma ROS 17.2/8 cells were cultivated in phenol red ‐ free medium supplemented with charcoal ‐ treated serum (strip.) or in normal medium supplemented with untreated serum (norm.). Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization

Domain requirements for transactivation. Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization

ERα binds on SFRE ‐ like sites of the opn promoter. Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization

Response of the opn promoter to the ERs. (A) ERα stimulates the expression of the opn promoter. Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization

Cross ‐ talk between ERs and ERRs. All ERs and ERRs bind to and activate transcription through the ERE site (at least a subset of these sequences in the case of the ERRs). Jean ‐ Marc Vanacker et al. EMBO J. 1999;18: ©1999 by European Molecular Biology Organization