Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? by Ching-Hon Pui, Charles G. Mullighan, William E. Evans, and Mary.

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Presentation transcript:

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? by Ching-Hon Pui, Charles G. Mullighan, William E. Evans, and Mary V. Relling Blood Volume 120(6): August 9, 2012 ©2012 by American Society of Hematology

Estimated frequency of specific genotypes in childhood ALL. Data were modified from Pui et al9 by including recently identified genotypes. Ching-Hon Pui et al. Blood 2012;120: ©2012 by American Society of Hematology

Use of germline variation to define ancestry (> 90% European ancestry for whites, > 10% Native American ancestry for Hispanics, > 70% African ancestry for blacks, and > 90% Asian ancestry for Asians). Ching-Hon Pui et al. Blood 2012;120: ©2012 by American Society of Hematology

At St Jude Children's Research Hospital, dosages of high-dose methotrexate are individualized based on the estimates of clearance to achieve a desired systemic exposure to the drug. Ching-Hon Pui et al. Blood 2012;120: ©2012 by American Society of Hematology