Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry by Po-Lin Chiu, George M. Bou-Assaf,

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Presentation transcript:

Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry by Po-Lin Chiu, George M. Bou-Assaf, Ekta Seth Chhabra, Melissa G. Chambers, Robert T. Peters, John D. Kulman, and Thomas Walz Blood Volume 126(8): August 20, 2015 ©2015 by American Society of Hematology

EM analysis of FVIII in complex with dimeric and monomeric D′D3. Po-Lin Chiu et al. Blood 2015;126: ©2015 by American Society of Hematology

Mapping of the D′D3 domain-binding site on FVIII by HDX-MS. Po-Lin Chiu et al. Blood 2015;126: ©2015 by American Society of Hematology