Date of download: 6/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Impact of Cognitive Behavioral Therapy for Social Anxiety Disorder on the Neural Dynamics of Cognitive Reappraisal of Negative Self-beliefs: Randomized Clinical Trial JAMA Psychiatry. 2013;70(10): doi: /jamapsychiatry Consolidated Standards of Reporting Trials Diagram for a Randomized Clinical Trial of Individual Cognitive Behavioral Therapy (I- CBT) vs Wait List (WL) Figure Legend:

Date of download: 6/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Impact of Cognitive Behavioral Therapy for Social Anxiety Disorder on the Neural Dynamics of Cognitive Reappraisal of Negative Self-beliefs: Randomized Clinical Trial JAMA Psychiatry. 2013;70(10): doi: /jamapsychiatry Experimental DesignComponents and structure of 1 autobiographical social situation trial. After each negative self-belief (NSB), participants provide a negative emotion rating from 1 = not negative to 5 = extremely negative. Figure Legend:

Date of download: 6/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Impact of Cognitive Behavioral Therapy for Social Anxiety Disorder on the Neural Dynamics of Cognitive Reappraisal of Negative Self-beliefs: Randomized Clinical Trial JAMA Psychiatry. 2013;70(10): doi: /jamapsychiatry Changes in Negative Emotion Intensity RatingsChanges in negative emotion intensity ratings for react negative self-beliefs and cognitive reappraisal of negative self-beliefs in patients with social anxiety disorder before and after individual cognitive behavioral therapy (I-CBT) vs wait list (WL). Negative emotion ratings after the offset of each stimulus were provided by participants in response to “How negative do you feel?” (1 = not at all, 2 = slightly, 3 = moderately, 4 = very much, and 5 = extreme). Error bars = standard error of the mean. a P <.05. b P <.001. Figure Legend:

Date of download: 6/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Impact of Cognitive Behavioral Therapy for Social Anxiety Disorder on the Neural Dynamics of Cognitive Reappraisal of Negative Self-beliefs: Randomized Clinical Trial JAMA Psychiatry. 2013;70(10): doi: /jamapsychiatry Changes in Brain ResponsesChanges in brain responses in the dorsomedial prefrontal cortex (DMPFC) and left dorsolateral prefrontal cortex (DLPFC) a priori cognitive reappraisal–related prefrontal cortical brain regions of interest in patients with social anxiety disorder before and after individual cognitive-behavioral therapy (I-CBT) vs wait list (WL). The dot represents the spherical region of interest mask used in the analysis. Blood oxygen level–dependent (BOLD) signal represents before to after I-CBT and WL change scores in BOLD signal responses. a P <.05. Figure Legend:

Date of download: 6/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Impact of Cognitive Behavioral Therapy for Social Anxiety Disorder on the Neural Dynamics of Cognitive Reappraisal of Negative Self-beliefs: Randomized Clinical Trial JAMA Psychiatry. 2013;70(10): doi: /jamapsychiatry Blood Oxygen Level–Dependent (BOLD) Signal Time SeriesBlood oxygen level–dependent signal time series in the dorsomedial prefrontal cortex (A) and left dorsolateral prefrontal cortex (B) during reappraise negative self-beliefs vs read neutral statements. I- CBT indicates individual cognitive-behavioral therapy and WL, wait list. Figure Legend:

Date of download: 6/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Impact of Cognitive Behavioral Therapy for Social Anxiety Disorder on the Neural Dynamics of Cognitive Reappraisal of Negative Self-beliefs: Randomized Clinical Trial JAMA Psychiatry. 2013;70(10): doi: /jamapsychiatry Differential Between-Group Baseline to Posttreatment ChangeDifferential between-group baseline to posttreatment change in dorsomedial prefrontal cortex–seeded context-dependent functional connectivity of cognitive reappraisal vs react negative self- beliefs. 1 Indicates medial prefrontal cortex; 2, right dorsomedial prefrontal cortex; 3, right middle frontal gyrus; 4, dorsomedial prefrontal cortex seed; 5, left hippocampus; and 6, left amygdala. For the whole-brain analysis, thresholding consisted of a per-voxel P <.005 and cluster volume threshold of 263 mm 3 or more. Within the amygdala search region, thresholding consisted of a per-voxel P <.03 and cluster volume threshold of 160 mm 3 or more. Figure Legend: