Producing Data 1.

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Presentation transcript:

Producing Data 1

Sources of Data - Goals Identify anecdotal data in a specific situation and explain why we should not use this type of data. Define what is meant by available data. Distinguish between experiments and observational studies. 2

Anecdotal Data and Available Data Anecdotal data represent individual cases that often come to our attention because they are striking in some way. Available data are data that were produced in the past for some other purpose but that may help answer a present question inexpensively. The library and the Internet are sources of available data. 3

Observational Studies and Experiments In an experimental study, we investigate the effects of certain conditions on individuals or objects in the sample. In an observational study, we observe the response for a specific variable for each individual or object. 4

Designing Experiments and Observational Studies - Goals In experiments, identify the units or subjects, treatments or factors and outcomes. Identify a comparative experiment and explain why they are used. Be able to apply the basic principles of experimental design: compare, randomize and repeat. Be able to identify common problems in design: – Bias – Over generalization Be able to identify matched pairs design and block design and explain why they are used. 5

Terms used in experiments Experimental units Treatment or factor – Level Outcome Statistically significant – An observed effect so large that it would rarely occur by chance. 6

Principles of Experimental Design 1.Control: Compare two or more treatments. 2.Randomize: use chance to assign experimental units to treatments. 3.Replication: Use enough experimental units in each group to reduce chance variation in the results. 7

Comparative Experiments 8 Experimental units Treatment Measure response Experimental units Control Measure response Treatment Measure response Compare results

Randomized Experiments In a completely randomized design, the treatments are assigned to all the experimental units completely by chance. 9 Experimental units Random assignment Group 1 Group 2 Treatment 1 Treatment 2 Compare results

Other Designs A matched pair design is when each experimental unit is matched with another one. A block is a group of experimental units that are similar. In a block design, the random assignment of experimental units to treatments is carried out within each block. Control what you can, block what you can’t control, and randomize to create comparable groups. 10

Sampling Design - Goals Be able to determine and explain when a probability sample, simple random sample or a stratified random sample is the preferred method. Be able to state when there is a response bias with obtaining a sample: convenience sample, nonresponse 11

Sampling Methods Probability Sample – Random Samples Simple Random Sample (SRS) - A (simple) random sample (SRS) of size n is a sample selected in such a way that every possible sample of size n has the same chance of being selected. Stratified Random Sample – 1) divide into groups, 2) SRS 12

Bias The design of a study is biased if it systematically favors certain outcomes. Convenience sample Undercoverage Nonresponse Your random sample needs to be representative of the population. Be careful about over generalization. 13

Managing Bias and Variability To reduce bias, use random sampling. To reduce variability of a statistic from an SRS, use a larger sample 14

Statistical Inference Sample has to be representative of the population – Randomize The experiment has to be performed in such a way that you can obtain the data that you are interested in. Perform the correct analysis. 15

Causality - Goals Be able to determine if a variable is lurking or confounding. Be able to explain an association in terms of – Causation – Common response – Confounding variables Apply the criteria for establishing causation. Association and causation are NOT the same thing. Interpret examples in terms of Simpson’s paradox. 16

Causality A lurking variable is a variable that is not among the explanatory or response variables in a study but that may influence the variables in the study. Confounding occurs when two variables are associated in such a way that their effects on a response variable cannot be distinguished from each other. 17

Causation Association does not mean causation! 18

Provide All the Critical Information Papers reporting scientific research are supposed to be short, with no extra baggage. Brevity, however, can allow researchers to avoid complete honesty about their data. Did they choose their subjects in a biased way? Did they report data on only some of their subjects? Did they try several statistical analyses and report only the ones that looked best? The statistician John Bailar screened more than 4000 medical papers in more than a decade as consultant to the New England Journal of Medicine. He says, “When it came to the statistical review, it was often clear that critical information was lacking, and the gaps nearly always had the practical effect of making the authors’ conclusions look stronger than they should have.” The situation is no doubt worse in fields that screen published work less carefully. 19