Company Introduction

Background Pharmaceuticals & Medical Devices: Consultancy, Testing & Research Services Independent company, privately owned by Mr WB Cartmell, currently Chairman of Wickham Laboratories Ltd Established in 1962, incorporated in 1963

A Brief History Started as diagnostic services support for veterinary practice Incorporated as a separate entity in s Vaccine egg production sister company, SPF, founded Pharmaceutical & food safety testing introduced Chemistry department opened GMP and GLP accreditations received Focus on pharmaceuticals and medical devices Appointment of new CEO, John McKenzie s 2000s to Present Relocation to Gosport and expansion of facilities GCP and UKAS accreditations received First MHRA and FDA audits Signatory to Concordat on Openness on Animal Research TestingCorporateRegulatory

Business & Growth £6.5M turnover

Aerial Photo of Wickham Laboratories Current site offers 4,000 square meters (42,000 square feet) of laboratory space with room to expand

Emphasis on Staff Wickham Laboratories employs around 110 staff School leavers Apprentices (see below) Graduates PhDs Training Required in-house and external training Cross-training between departments External higher degrees Further Education Apprenticeship at Highbury College in Portsmouth NVQ level 3, studying for Edexcel Btec Diploma in Applied Science

Emphasis on Quality Compliant with: Registered & Audited by: Quality is of the utmost importance to us and our customers. We are audit ready at all times, performing ~40 client audits per year. Inspected by: &

Industry Profile Pharmaceutical products, medical devices & herbal products Biological preparations/fluids Consumer products EVM (surface/air sampling) Water Pharmaceutical, medical device & herbal remedy manufacturers Biotechnology companies CROs & other contract labs Clinical trial facilities NHS Types of TestingTypes of Clients

Microbiology and In-vitro Services in-vitro & Alternatives Bacterial Endotoxin (LAL) Cytotoxicity ( ) MAT QC Testing TAMC/TVC Bioburden Determination Sterility Testing Validation Projects Antimicrobial Efficacy Preservative Efficacy Log Reduction Testing BI Enumeration Integrity Testing Microbial IDs Stability Studies

Toxicology Services Abnormal Toxicity USP Plastics Class I-VI Quality of existing products Registration of new formulations Research for new medicines & devices Potency Bioassays Rabbit Pyrogen Test

Toxicology & Animal Welfare The 3 Rs Animal welfare is highest priority Regular vet visits (scheduled and unscheduled) Number of animals used in testing has been reduced by over 50% since early 1990s Alternative non-animal method (LAL) has replaced the majority of pyrogen testing Environment enrichment Ongoing research into alternative methods via dedicated in vitro department (MAT)

Research & Consulting Services 40+ years of consulting expertise Environmental monitoring Process validation Regulatory support Dedicated onsite R&D department New technology & techniques In vitro method validation Microbiology projects

Knowledge Transfer Partnership (KTP): Novel Assay Entered into KTP with University of Southampton in 2014 Employee will gain valuable research expertise and develop new non-animal assays for our use Will replace existing animal test for toxin testing Ethically positive and a unique future selling point for toxicology services One of several planned collaborations

Strategy Investment in novel technologies & expansion Carefully selected partnerships Industry association memberships & networking

Sustainability Electronic reporting 43% reduction in postage, paper and ink since 2012 Reviewing Boiler Air handling Plans to move to LED and PIR lighting as appropriate Green transport schemes with Gosport Borough Council Suppliers ISO or ISO 9001 Questionnaire - links to environmental organisations Recycling Clean glass, polystyrene, WEEE Sourcing metal skip