Red blood cells mediate the onset of thrombosis in the ferric chloride murine model by Justin D. Barr, Anil K. Chauhan, Gilbert V. Schaeffer, Jessica K.

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Red blood cells mediate the onset of thrombosis in the ferric chloride murine model by Justin D. Barr, Anil K. Chauhan, Gilbert V. Schaeffer, Jessica K. Hansen, and David G. Motto Blood Volume 121(18): May 2, 2013 ©2013 by American Society of Hematology

Visualization of the carotid artery endothelial surface by SEM. (A) The image shows a longitudinal section from an untreated mouse, approximately 1.5 mm long. Justin D. Barr et al. Blood 2013;121: ©2013 by American Society of Hematology

SEM visualization of thrombotic material in the mouse carotid artery induced by FeCl3 application. Justin D. Barr et al. Blood 2013;121: ©2013 by American Society of Hematology

Adhesion of RBCs to the endothelial surface following FeCl3 application. Justin D. Barr et al. Blood 2013;121: ©2013 by American Society of Hematology

RBC fragment formation in mesenteric venules visualized by brightfield intravital microscopy. Justin D. Barr et al. Blood 2013;121: ©2013 by American Society of Hematology

Following FeCl3 application, platelets bind to RBC-derived structures rather than to the intact endothelial surface. Justin D. Barr et al. Blood 2013;121: ©2013 by American Society of Hematology

Rapid platelet aggregation on RBC-derived material visualized by brightfield intravital microscopy and SEM. (A-F) The elapsed time from the initial frame (A) is as indicated (seconds). Justin D. Barr et al. Blood 2013;121: ©2013 by American Society of Hematology

SEM visualization of carotid artery FeCl3-induced thrombosis in VWF-deficient (A), and GPIb-α extracellular domain–deficient mice (B). Justin D. Barr et al. Blood 2013;121: ©2013 by American Society of Hematology