Skin-Derived Fibroblasts for the Treatment of Refractory Achilles Tendinosis: Preliminary Short-Term Results by Haron Obaid, Andrew Clarke, Peter Rosenfeld,

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Presentation transcript:

Skin-Derived Fibroblasts for the Treatment of Refractory Achilles Tendinosis: Preliminary Short-Term Results by Haron Obaid, Andrew Clarke, Peter Rosenfeld, Christopher Leach, and David Connell J Bone Joint Surg Am Volume 94(3): February 1, 2012 ©2012 by The Journal of Bone and Joint Surgery, Inc.

Flow diagram for the patients with unilateral involvement, demonstrating the enrollment, allocation, follow-up, and analysis stages of the trial. Haron Obaid et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

Flow diagram for the patients with bilateral involvement, demonstrating the enrollment, allocation, follow-up, and analysis stages of the trial. Haron Obaid et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

Skin-derived fibroblasts on day 0 (Fig. 3-A) and eleven days after culture (Fig. 3-B) (magnification, ×200). Haron Obaid et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

The preliminary ultrasound shows severe tendinosis manifested by marked fusiform thickening, hypoechoic changes, and longitudinal intrasubstance tears. Haron Obaid et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

An ultrasound examination performed six months after cell therapy, showing a reduction in tendon thickness, increased echotexture, and resolution of the intrasubstance tears. Haron Obaid et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

The VISA scores (y axis) before and after treatment for the cell therapy group and the control group (intergroup) and between baseline and six months after treatment (within-group). Haron Obaid et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

The VAS scores (y axis) before and after treatment for the cell therapy and control groups (intergroup comparison) and between baseline and six months after treatment (within-group). Haron Obaid et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.